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FIBRIN

FIBRIN. Drew Sivertsen. Amino Acid Sequence of Fibrin. Structure of Fibrin. It consists a blood-borne glycoprotein composed of three pairs of non-identical polypeptide chains. They are held together by a very thin thread

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FIBRIN

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  1. FIBRIN Drew Sivertsen

  2. Amino Acid Sequence of Fibrin

  3. Structure of Fibrin • It consists a blood-borne glycoprotein composed of three pairs of non-identical polypeptide chains. They are held together by a very thin thread • Made up mostly of blood protein fibrinogen, that is turned into fibrin when the blood clots • Fibrinogen molecules are made up of oftwo sets of “disulfide-bridged” Aalpha-, Bbeta-, and gamma-chains • "This is among the most extensible, or stretchy, of polymers that anyone has ever found," John W. Weisel, PhD, Professor of Cell and Developmental Biology

  4. Structure of Fibrin cont’d single alpha helices beta sheets (yellow) bound ligands The chemical structures of the ligands are Ca+2 ion, alpha-D-mannose (C6H12O6), and D-glucosamine (C8H15NO6).

  5. Fibrin’s Function • Quickly controls bleeding at an injury site • When an individual has an open cut or gash, the fibrous protein forms a mess that plugs the wounded area • This “plug” is known as a blood clot • Haemostasis (bringing bleeding to a halt) • Brinolysis (breaking down clots after damage has been repaired)

  6. Organism’s that use Fibrin • Any organism that has blood flowing thorough its body use’s fibrin which contains Fibrinogen • It plays an essential role in the survival or organisms/living creatures that have a steady flow of blood • Humans, cats, dogs, pigs, horses, giraffes, seagulls…ect.

  7. Why I chose Fibrin • I chose Fibrin because of its name. When I read “Fibrin” on the proteins list, I had to have it because it had a very short name. Many of the other proteins I have trouble sounding out and even spelling their names. It was love at first sight and I knew I had to have Fibrin in my hands for this project.

  8. Other Important facts about Fibrin • If our bodies create too much Fibrin, it can result in thrombosis which can obstruct the flow of blood in the circulatory system • If our bodies create too little Fibrin, then our bodies might be prone to hemorrhaging( profuse bleeding from the blood vessels). • The most well-known hereditary abnormality that is related to Fibrin id the genetic disorder that causes hemophilia (blood fails to clot normally)

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