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Fibrin

Exemple = 1 Image. Platelet. Erytrocytes. Leukocytes. Fibrin. Cholesterol. Mix Cell-Fibrin. LIMITATIONS. 1- Analysis of the main aspirated piece of the thrombus only. 2- Potential distortion during thrombo-aspiration. 3- Younger thrombus could be superimposed with an older one.

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Fibrin

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  1. Exemple = 1 Image Platelet Erytrocytes Leukocytes Fibrin Cholesterol Mix Cell-Fibrin

  2. LIMITATIONS 1- Analysis of the main aspirated piece of the thrombus only 2- Potential distortion during thrombo-aspiration 3- Younger thrombus could be superimposed with an older one 4- No increase of the % of erythrocytes with time (“Red Thrombi”)

  3. A crucial role for early anti-thrombotic treatment Platelet and thrombin inhibition with fast acting drugs especially in early presenters <3 hours

  4. Conclusion • First human confirmation of the generally accepted pathogenesis of clot formation in vivo in patients presenting an acute coronary thrombosis (STEMI). • Highlight the crucial role of fast-acting platelet and thrombin inhibitor in STEMI presenters • Did not impact reperfusion in this limited size mechanistic study (n=911) • A potential prognostic marker that is linked to short and long-term mortality in previous study (Kramer et al. Circulation 2009)

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