Tuesday, March 6, 2012

1. Tuesday, March 6, 2012 Open to entry- Protein Networks from yesterday Homework: • Cell Transport retakes in tutorial- LAST DAY • Quiz on Protein Pathways/Protein Structure- FRI • Serotonin Pathway worksheet- due on Block Day

2. “Coat Color in Labrador Retrievers” Cocoa Midnight

3. Guiding Question: “How does variation exist between organisms?” Read: “Coat Colors in Labrador Retrievers” to help you answer this question.

4. Vocab to know for reading. • Pigment = A substance, such as chlorophyll or melanin, that produces a characteristic color in plant or animal tissue. • Skin and Hair pigments are produced in cells called melanocytes. • Synthesize = to put together.

5. Labrador (dog) pigmentation Yellow pigment tyrosinase Tyrosine Dopaquinone What will be the dog’s coat color? TRP-2 BLACK Brown pigment TRP-1 Boxes = metabolites Arrows = enzymes that change the metabolites Black pigment

6. What would happen if the enzyme TRP – 1 was missing? Yellow pigment tyrosinase Tyrosine Dopaquinone TRP-2 Brown pigment TRP-1 Boxes = metabolites Arrows = enzymes that change the metabolites Black pigment Black pigment What color is the dog’s coat? Brown

7. So what would happen if the enzymes TRP – 1 and TRP-2 were both missing? Yellow pigment tyrosinase Tyrosine Dopaquinone TRP-2 Brown pigment Brown pigment TRP-1 Boxes = metabolites Arrows = enzymes that change the metabolites Black pigment Black pigment What color is the dog’s coat? Yellow

8. Entry 17-Protein Pathways Practice- 3/6/12 Make an entry: Entry 17: Protein Pathways Practice- 3/6/12 See attached

9. Pigment Metabolic Network for the Imaginary Bioflower Blue Flower Purple Flower Where is the variation in these flowers? Blue and Purple Flowers (Color)

10. Bioflowers A colorless starting molecule is converted by enzyme X to blue pigment. Next, enzyme Y converts the blue pigment to purple pigment. 1a.Diagram of the pathway. (include a key) Colorless Compound Blue Pigment Purple Pigment X Y

11. 1b.Give an explanation for a blue flower. Enzyme Y not available or not working

12. “Roundbuds”

13. Roundbuds In another type of wildflower, the roundbud, red pigment is synthesized from a white precursor by enzyme Q. • Draw the enzyme pathway for the roundbud. It was believed that all roundbuds were red until a knowledgeable, observant teenager discovered a meadow full of white-flowered roundbuds. 2. Using your knowledge of the synthesis pathway for red pigment, give an explanation for the white roundbud variety.

14. In another type of wildflower, the roundbud, red pigment is synthesized from a white precursor by enzyme Q. 2a. Draw Enzyme Pathway Red Pigment White Precursor Q

15. 2b. It was believed that all roundbuds were red until a knowledgeable, observant teenager discovered a meadow full of white-flowered roundbuds.

16. White Precusor Red Pigment Q Enzyme Q is not working- therefore no conversion to red pigment. 2b. Using your knowledge of the synthesis pathway for red pigment, give an explanation for the white roundbud variety.

17. YELLOW PIGMENT IS CONVERTED BY ENZYME Z INTO BROWN PIGMENT • YELLOW CAN ALSO BE CONVERTED BY ENZYME W INTO RED PIGMENT • BROWN PIGMENT IS CONVERTED BY ENZYME X INTO BLACK PIGMENT • BROWN CAN ALSO BE CONVERTED BY ENZYME Y INTO ORANGE

18. YELLOW PIGMENT Chupacabra Coat Color Z W BROWN PIGMENT RED PIGMENT • Yellow= no Z or W • Brown= no X or Y, W • RED= no Z X Y BLACK PIGMENT ORANGE PIGMENT

19. #3. Fancy flowers a. • Red with white spots • No spots, red only RED-WHITE SPOTS RED-BLUE SPOTS RED T S

20. #4 • 1,2 • A,B, C, D • All except F • 1, 3 A B C 3 1 4 2 E F D 5

21. Make an entry- Entry 18: Human Metabolic Networks- 3/6/12 Substrate Enzyme Product Add to last question on back: How is a MAO inhibitor used to treat depression?