40 likes | 147 Views
Estrogen receptor-a signaling in osteoblast progenitors stimulates cortical bone accrual. Osteoscoop - Issue N°295 – July 2013. Mature osteoblast. Osteoblast progenitor. Unliganted ER- a. Cortical bone accrual. Periosteum osteoblastogenesis. Mature osteoblast.
E N D
Estrogen receptor-a signaling in osteoblast progenitors stimulates cortical bone accrual Osteoscoop - Issue N°295 – July 2013
Mature osteoblast Osteoblastprogenitor Unliganted ER-a Cortical boneaccrual Periosteum osteoblastogenesis
Mature osteoblast Osteoblastprecursor Unliganted ER-a Cortical boneaccrual Periosteum osteoblastogenesis Wnt LRP5/6 P P P b-Catenin b-Catenin b-Catenin Nucleus
Mature osteoblast Osteoblastprecursor Unliganted ER-a Cortical boneaccrual + Periosteum osteoblastogenesis Wnt LRP5/6 P P P b-Catenin b-Catenin b-Catenin + Unliganted ER-a Nucleus