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CLINICAL AND BIOLOGICAL FACTORS WITH PROGNOSTIC VALUE IN PRIMARY SPLENIC LYMPHOMA

CLINICAL AND BIOLOGICAL FACTORS WITH PROGNOSTIC VALUE IN PRIMARY SPLENIC LYMPHOMA. First Author: Vanga Carmen Adina Author: Hutu Simona Botoman Maria

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CLINICAL AND BIOLOGICAL FACTORS WITH PROGNOSTIC VALUE IN PRIMARY SPLENIC LYMPHOMA

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  1. CLINICAL AND BIOLOGICAL FACTORS WITH PROGNOSTIC VALUE IN PRIMARY SPLENIC LYMPHOMA First Author: Vanga Carmen Adina Author: Hutu Simona Botoman Maria Muresan Ioana Alexandra Simon Ionela Anca Coordinator: Dr. Demian Smaranda

  2. Backround • Of all the malignant tumors of the spleen, the most common morphological entity is malignant lymphoma, most often with regard to a Non Hodgkin`s Lymphoma (NHL) • Tumor invasion of the spleen is usually seen in the evolution of nodal or extranodal NHL onset • Primary splenic lymphoma is approximately 1-2% of NHL

  3. Patients and method • retrospective cohort study - patients diagnosed, treated and followed in the Ist Medical Clinic - Hematology, during 2000-2010 • the study was referring mainly on Marginal Zone Lymphoma of the Spleen (MZLS) • evaluation of the incidence of various potential prognostic and predictive factors (clinical, biological, morphological factors)

  4. ResultsPrimary splenic NHL, the distribution of histological subtypes

  5. Primary splenic NHL, the distribution by gender

  6. Primary splenic NHL, the distribution by age

  7. Clinical and biological parameters with prognostic potential in splenic NHL

  8. Clinical and biological parameters with prognostic potential in splenic NHL

  9. LSZM prognosis stratification by prognostic index proposed by integruppoitalianolimfomi – iil

  10. Conclusions • Primary splenic NHL is 5.55% of total NHL • most common histological subtype was represented by marginal zone lymphoma of the spleen (MZLS) • compared with other types of NHL spleen, MZLS was diagnosed more frequently at a young age and female patients

  11. Conclusions • to assess the incidence of clinical prognostic factors in MZLS subgroup were found to differ significantly from the other spleen histology NHL.

  12. Conclusions • careful morphological evaluation, along with immunohistochemical and flow cytometric study appears as an item of great value in the positive and differential diagnosis

  13. Thank you for your attention !

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