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Pathophysiology

Pathophysiology. The cause is unknown in most MVP patients. In some patients, it appears to be a genetically determined collagen disorder. It has been linked to the reduced production of type III collagen. MVP is a frequent finding in patients with heritable connective tissue disorders

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Pathophysiology

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  1. Pathophysiology • The cause is unknown in most MVP patients. • In some patients, it appears to be a genetically determined collagen disorder. • It has been linked to the reduced production of type III collagen. • MVP is a frequent finding in patients with heritable connective tissue disorders • Marfan syndrome, osteogenesisimperfecta, and Ehler-Danlos syndrome

  2. Pathophysiology • In most patients with MVP, the mitral apparatus (valve leaflets and chordae) is subject to myxomatous degeneration. • In myxomatous degeneration, collagen forms abnormally, causing thickening, enlargement, and redundancy of the leaflets and chordae. • During systole, the redundant leaflets prolapse into the left atrium.

  3. Pathophysiology

  4. Pathophysiology • The posterior leaflet is more often affected than the anterior, and the mitral valve annulus is usually greatly dilated. • Mitral regurgitation occurs when there is leakage of blood through the valve opening. • Severe mitral regurgitation can lead to heart failure and abnormal heart rhythms.

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