1 / 7

Exploring the association of the CYP1A1-CYP1A2 locus with blood pressure in CoLaus

Exploring the association of the CYP1A1-CYP1A2 locus with blood pressure in CoLaus. Diana Marek and Murielle Bochud. Background information. High blood pressure leads to hypertension, a major modifiable cardiovascular risk factor. In Switzerland, hypertension affects 1 in 3 adults.

margo
Download Presentation

Exploring the association of the CYP1A1-CYP1A2 locus with blood pressure in CoLaus

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Exploring the association of the CYP1A1-CYP1A2 locus with blood pressure in CoLaus Diana Marek and Murielle Bochud

  2. Background information • High blood pressure leads to hypertension, a major modifiable cardiovascular risk factor. • In Switzerland, hypertension affects 1 in 3 adults. • Hypertension increases the risk of stroke, myocardial infarction and kidney diseases. • So far, the exact biological mechanism underlying hypertension is unknown in 95% of cases. • Hypertension aggregates in families, which suggests that genes play a role. • Genetic association studies are used to identify new blood pressure candidate genes.

  3. New loci associated with blood pressure(International Consortium on blood pressure genetics) Significance of the statistical association 29 genetic variants identified Chromosomes Includes data from the CoLaus study in Lausanne Ehret et al, Nature 2011, September 11 Genome-wide meta-analysis for systolic and diastolic blood pressure

  4. 29 SNPs genome-wide significant in 28 loci 8/29 SNPs are in high LD (r2 > 0.8) with a non-synonymous coding SNP. Some evidence that the 29 SNPs are enriched for eSNPs. The phenotypic variance explained by the 29 variants is ~1%.

  5. Locus 1: association signal with blood pressure at a locus where the causal gene is NOT clear Ehret et al, Nature 2011

  6. Locus 2: the causal gene is NOT clear as well

  7. Aims of this project • to analyze the association of two ICBP loci (rs1378942 and rs11191548) with systolic and diastolic blood pressure in CoLaus. • to search the literature on the CYP1A1,CYP1A2 and CSK genes and to choose the most likely causal gene for the rs1378942 locus. • to search the literature on the CYP17A1, C10orf32, AS3MT, CNNM2 genes and choose the most likely gene for the .rs11191548 locus. • to conduct stratified analyses by selected covariates (the choice of covariates needs to be decided by the group) to confirm the most likely causal gene.

More Related