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Enhancing Myosin Activation and Cardiac Contractility: Implications for Heart Failure

Enhancing Myosin Activation and Cardiac Contractility: Implications for Heart Failure. Heart Failure. Traditional Treatment for Acute Decompensated Heart Failure. Traditional Treatment for Acute Decompensated Heart Failure (cont).

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Enhancing Myosin Activation and Cardiac Contractility: Implications for Heart Failure

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  1. Enhancing Myosin Activation and Cardiac Contractility: Implications for Heart Failure

  2. Heart Failure

  3. Traditional Treatment for Acute Decompensated Heart Failure

  4. Traditional Treatment for Acute Decompensated Heart Failure (cont)

  5. Traditional Treatment for Acute Decompensated Heart Failure (cont)

  6. Traditional Positive Inotropic Agents

  7. Omecamtiv Mecarbil: A Novel Selective Cardiac Myosin Activator

  8. Omecamtiv Mecarbil

  9. Omecamtiv Mecarbil: Echocardiogram Changes in Healthy Volunteers

  10. Omecamtiv Mecarbil: Echocardiographic Changes in Patients With Stable Heart Failure and LV Dysfunction

  11. ATOMIC-AHF: Study DesignRandomized, Double-blind, Placebo-controlled, SequentialCohort Study

  12. ATOMIC-AHF-Primary End Point:Dyspnea ResponsePaired Placebo

  13. Safety Concerns

  14. Supraventricular and Ventricular Tachyarrhythmias

  15. COSMIC-HF: Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure

  16. References

  17. Abbreviations

  18. Abbreviations (cont)

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