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Effects of Renin System Inhibitors on the Renin System

Effects of Renin System Inhibitors on the Renin System. DRI. Angiotensinogen. Ang I. Non ACE pathways. Renin. ACE. ACEIs. Feedback loop. Ang II. ARBs. AT 1. Receptor.

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Effects of Renin System Inhibitors on the Renin System

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  1. Effects of Renin System Inhibitors on the Renin System DRI Angiotensinogen Ang I Non ACE pathways Renin ACE ACEIs Feedback loop Ang II ARBs AT1 Receptor DRI=direct renin inhibitor; Ang=angiotensin; ACE=angiotensin converting enzyme; ACEI=angiotensin converting enzyme inhibitor; ARBs=angiotensin receptor blocker Presented at the World Congress of Cardiology 2006, Barcelona Spain

  2. Addition of DRI to Other Antihypertensive Agents Does Not Compromise Tolerability Incidence of adverse events (%) 40.7% 40.4% 33.8% 33.4% 31.6% 30.0% 29.7% 30.3% 278 277 311 178 555 1464 357 187 Ramipril ARB HCTZ Amlodipine +DRI +DRI +DRI +DRI Data pooled across doses: ARB - Valsartan or lrbesartan

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