Optimal Immune Support with Reishi: Enhancing Immune Functions

1. Optimal Immune System Support Product Training

2. The Human Immune System ...…is a complicated network of cells, antibodies and proteins that serves following three main functions: 1. Removes waste and harmful material, to ensure the normal function of the body. 2. Defends against pathogens - bacteria, fungi and virus. 3. Kills and removes dead and altered cells.

3. The Human Immune System ......is delicately balanced by a very sophisticated feedback regulation and control system • Prolonged immune deficiency can lead to infection, frequent sickness, lack of vigor and energy and impaired metabolism. • On the other hand, chronic activation of immune system can also lead to certain autoimmune conditions such as arthritis, lupus, nephritis, allergy, etc.

4. Immune Cells Recognize and Destroy: Pathogens and Altered Cells Immune cell “swallows” foreign invader Chemical message alerts immune system that an invader is present

5. Reishi Mushroom Reishi (Ganodermalucidum) mushroom is a fungus occurring as a shelf-like form on the sides of trees and stumps in densely wooded mountains with high humidity and low light. The spores of Reishi have such tough outer husks that germination is next to impossible, which accounts for its rarity.

6. Types of Reishi There are 62 types of Reishi, of which six are most common: RED BLACK BLUE WHITE YELLOW PURPLE RED Reishi is preferred because it can produce the highest quality extract and has been subject to the most scientific evaluation

7. Traditional Use Reishi, also known as Lingzhi, is one of the most valued herbal products in Traditional Chinese Medicine (TCM) Reishi’s earliest herbal remedies were recorded between 206 B.C. - 8 A.D. In Taiwan, families often give Reishi to their aging grandparents

8. Cultivation of Reishi In 1971, Yukio Naoi, a researcher of the Kyoto University in Japan, successfully developed the artificial cultivation of Reishi, which resulted in reproducible and consistent production of Reishi.

9. Reishi Spores • These highly active substances are the essence of Reishi. • They are the reproductive cells that are released at maturity. • However, Reishi spores are protected by an extremely hard shell which prevent us from optimally absorbing the actives.

10. Compounds Identified in Reishi Mushrooms

11. Research Findings: Reishi Mushroom & Extracts • Cell support • Immune dysfunction-related diseases • Liver protection • Nervous system dysfunction • Cardiovascular protection and blood sugar support

12. Clinical studies on Reishi Reishi stimulates the immune system’s ability to recognize pathogens and altered cells Reishi provides complementary therapy to promote health and longevity • stimulates the formation of antibodies • stimulates the ability of proliferation of immune cells • modulates the function of T cells and NK cells Wang SY, et al. International Journal of Cancer 1997;70(6):699-705. Lu Z, Lin ZB. 1994 International Symposium on Ganoderma Research, October 24-26, 1994, Beijing Medical University, Beijing , China, Program and Abstracts, p. 82. Kupin, V. (1992). The 4th International Symposium onGanodermalucidum, Hyatt Regency hotel, June 10, 1992, Seoul, Korea, Program and Abstracts, pp. 36-39. Yang QY, Wang, M. M. (1996). 1996 Taipei International Ganoderma Research Conference, Taipei International Convention Center (TICC), August 15-15, 1996, Abstracts, Special Lecture.

13. Optimal Immune System Support * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

14. Uses the best Reishi species: RED Reishi or Ganodermalucidum • Use of the best Reishi cultivation method: solid tree trunk, organic cultivation for 120-200 days • Free of heavy metals and unwanted microbial contamination * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

15. Uses Pharmanex’s proprietary manufacturing process to extract active components from Reishi * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

16. Cracked Reishi Spores Reishi spores 100% Cracked spores — 3000X magnification under an electronic microscope * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

17. Proprietary Formula • Contains Reishi spores (100% cracked) • Standardized to • 6% Reishitriterpenes • 13.5% Reishi polysaccharides

18. ReishiMax Clinical Studies A comparative study demonstrated enhanced immune functions by ReishiMax: • Increased serum antibodies* • Stimulated proliferation of immune cells* • Modulation of the T cell functions* • Enhanced the NK cell functions* * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

19. 5000 p<0.001 by ANOVA 4000 3000 +822% +799% Interleukin-2(pg/ml) 2000 +405% 1000 p=0.12 0 Placebo 0.585 1.170 ReishiMax GLP 2.925 0.585(g/kg) Other Reishi ReishiMax enhances cell-mediated immune functions* By Medical Institute at National Taiwan University * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

20. Other Reishi product mAU GA 200 100 0 0 10 20 30 40 50 min ReishiMax mAU GA Ganoderol acid DM-std Ganoderol B 100 50 0 0 10 20 30 40 50 min Higher Amount of Actives * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

21. 90% 90% 71% 80% 70% 51% 60% 50% 40% 30% 20% 10% 0% ReishiMax Reishi A Reishi B Higher Solubility By Pharmanex Research Center at Shanghai Medical University * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

22. Competitive Advantage • 6S process • Best natural Red Reishi species • Organic cultivation • Cracked spores • Proprietary manufacturing technology • Highest level of actives on the market • Scientifically proven * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

23. Recommended Usage Take twice daily with meals: • 1 capsule each time for health maintenance • 2 capsules each time for immune modulation Safe and well tolerated at the recommended dosage * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

24. Taken together, ReishiMax and Tegreen 97 provide a comprehensive cellular health maintenance program* * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

25. THANK YOU