1 / 11

GRAM POSITIVE COCCI

GRAM POSITIVE COCCI. Gram positive and negative bacteria: The cell wall very different: . Peptidoglycan very strong, thick and rigid. . Teichoic acid surface antigen. Species cause of human disease:. Staphylococcus aureus Streptococcus pneumoniae Streptococcus pyogenic ect.

mataa
Download Presentation

GRAM POSITIVE COCCI

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. GRAM POSITIVE COCCI Gram positive and negative bacteria: The cell wall very different: . Peptidoglycanvery strong, thick and rigid. . Teichoic acid surface antigen.

  2. Species cause of human disease: • Staphylococcus aureus • Streptococcus pneumoniae • Streptococcus pyogenic • ect

  3. Structure and function • Capsule antiphagocytosis • Peptidoglycan stimulate production of endogenous pyrogens • Protein spesific:A,M,F antiphagocytosis,anticomplementary • Teichoic acid attachment to mucosal

  4. Pathogenesis and Immunity The virulence is determined by: a variety of structural molecule and elaborated toxins and enzymes.  virulence factors

  5. Toxins - Exotoxin : 1. Cytotoxin 2. Enterotoxin food poisoning .resistant to gastric &jejunal enzymes. .heat stable .stimulate intestinal peristalsis

  6. Enzymes . Coagulase  fibrin layer . Catalase  H2O2 . Hyaluronidase  spreading factors . Lipase . Fibrinolysin . Penicillinase . Ig A protease . Hemolysin : Streptolysin O  antigenic

  7. Important features of pathogenesis • Staphylococcus aureus 1. Pyogenic (abscess) - local  skin infection surgical wound infection - disseminated  sepsis 2. Toxigenic  food poisoning

  8. Staphylococcus epidermidis Pyogenic  iv catheter sites & prostetic devices • Staphylococcus saprophyticus Pyogenic  UTI(Urinary Tract Infection )

  9. Streptococcus pyogenes 1.Pyogenic . Local : skin,pharing . Disseminated : sepsis 2. Toxigenic 3. Immune-mediated(post Streptococcal infection,non suppurative)

  10. Poststreptococcal disease Immunologic response to streptococcal M protein that cross-react with human tissues. • Acute Glomerulonephritis antigen-antibody complexes on glomerular. • Acute Rheumatic Fever autoimmune disease

  11. Streptococcus pneumoniae Pyogenic : . Pneumonia . Otitis media . Meningitis

More Related