1 / 14

Shared Health Research Information Network

Shared Health Research Information Network. Andrew McMurry, MS SHRINE Architect Harvard Medical School Center for BioMedical Informatics Children’s Hospital Informatics Program Harvard/MIT HST Boston University Bioinformatics PHD Student Andrew_McMurry(@) hms.harvard.edu.

mauli
Download Presentation

Shared Health Research Information Network

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Shared Health Research Information Network Andrew McMurry, MSSHRINE ArchitectHarvard Medical School Center for BioMedical Informatics Children’s Hospital Informatics Program Harvard/MIT HST Boston University Bioinformatics PHD StudentAndrew_McMurry(@) hms.harvard.edu Current Status, Demo, and Open Source

  2. History of the SHRINE world in 1 minute • Partners RPDR  i2b2 Data Repository • Shawn Murphy et all (wont steal their thunder here) • Everyday patient encounters  huge research cohorts • SPIN  cross-hospital query model • Extract, Transform <de-identifiy, autocode>, Load • Federated query over multiple independent hospitals • Harvard CTSA funded • Recombinant deploying i2b2 across the country • Overly simplified: clinical data repository + federated query = SHRINE

  3. SHRINE Technical Architecture • Bird’s Eye View • Leverage local i2b2 deployments • Broadcast queries and aggregate responses across autonomous sites as if they were “one clinical data warehouse” • There is no central database • Connect sites in a peer-to-peer or hub-spoke fashion

  4. Technical Architecture, “cell” view Architecture

  5. Current Status : in BETA! • East Coast : Harvard Effort • BETA system running at Harvard across BIDMC, Children’s, and Partners representing both BWH and MGH. • Last AUG: • Prototype 1 year of data with demographics and diagnosis • IRB approval for demonstration only • NOW • Patient data from 2001+ • Demographics, Diagnosis, Medications, some Labs • Full IRB approvals

  6. Current Status : in BETA! • Demo use cases, things to think about….. • Lung cancer cases  requesting biospecimens • Irritable Bowel Syndrome  requesting sized cohorts • Pediatric rheumatology  Creating national registry

  7. Current Status • West Coast : CICTR Effort • University of Washington • UCSF • UC Davis • Nick Anderson et all

  8. Current Status • National Registry : Pediatric Rheumatology • “Grand Opportunity” Grant • 60 institutions, 2 years • SHRINE has been selected as inter-institutional glue • Consented patients, prospective data collection • Shared Virtual Machine Hosting

  9. SHRINE Open Source : brewing in the background Fast recap of 2006 and 2009 Open Source proposals: • Write documentation as if we are writing code stubs • Preconditions + • Steps (Algorithm) + • Post-conditions = Use Cases or “Scenarios” • Test driven development • Write the test first • Implement second • Regression test everything all the time • Continuous Integration • Test everything every time you change any code

  10. SHRINE Open Source Process  Leveraging routine development activities • Public access to bug tracking system • Public access to latest source code • Public mailing lists • Shrine-users • Shrine-developers • Shrine-announce • Test Driven Development • Continuous integration (daily builds of the complete software)

  11. Acknowledgements: Core SHRINE team • Zak Kohane (SHRINE Lead / HMS) • Griffin Weber (HMS CTO / bidmc) • Shawn Murphy (I2B2 CRC / partners) • Dan Nigrin (Children’s CIO) • Ken Mandl (Public Health Use Cases/ CHIP IHL) • Sussane Churchill (I2B2 Executive director) • Doug Macfadden (HMS CBMI IT Director) • Matvey Palchuck (Ontology Lead / HMS) • Andrew McMurry (Architect / HMS) • Could give an entire talk on all the collaborators, multi-institutional effort. Asking forgiveness from those not listed

  12. Acknowledgements: Core SPIN team • Zak Kohane (SPIN PI / HMS) • Frank Kuo (PSL Program Director / BWH) • John Gilbertson (PSL Pathologist / MGH) • Mark Boguski (PSL Pathologist / BIDMC) • Antonio Perez (PSL Pathologist / Children’s) • Mike Banos (PSL Developer / BWH ) • Ken Mandl (Biosurviellance PI/ Children’s) • Clint Gilbert (Biosurviellance Dev Lead / Children’s) • Greg Polumbo (SPIN Developer/ HMS) • Ricardo Delima (SPIN Developer / NCI at HMS) • Britt Fitch (SPIN Developer / HMS • http://spin.chip.org/community.html

  13. Acknowledgements: Core I2b2 team • https://www.i2b2.org/about/structure.html

  14. Thank You • http://catalyst.harvard.edu/shrine • Andrew_McMurry (@) hms.harvard.edu

More Related