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Advancing Organ Preservation through Machine Perfusion: Evaluation and Implementation Strategies

Explore the benefits of machine perfusion in expanding organ acceptance criteria and assessing extended criteria organs. This technology development involves staff training and competency to ensure self-sufficiency. Gain insights into responsible funding and driving the wider applicability of organ perfusion.

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Advancing Organ Preservation through Machine Perfusion: Evaluation and Implementation Strategies

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  1. Machine perfusion- Evaluation criteria

  2. Machine perfusion- Benefit assessment Expand organ acceptance criteria Assess function of “extended criteria” organs

  3. From aspiration to national clinical reality?

  4. Technology development

  5. Staff training and competency • Self sufficiency • Staff training

  6. Staffing model ? Advanced practitioner in organ preservation and transplantation Donor management Organ perfusion Organ preservation Responsible for “the machine(s)”

  7. Funding

  8. Summary • Machine perfusion is here to stay • In situ and ex situ perfusion required • Normothermic perfusion is likely to be the future • Start simple – NRP • Cheap intervention that may benefit all organs • Further technological refinements are needed • Graft assessment and modulation • Wider applicability

  9. The revolution begins this year

  10. The way forward? • First step • Expand NRP utilisation in the three centres • Allow technological development • Establish training programme • Supportive data for wider applicability • Second step • Expand to other centres adding NMP as it becomes available

  11. How? • NHSBT support • Organ acceptance and distribution • CUSUM exception to promote innovation • Funding • Step 1: £ 40k – capital costs £ 150k – staff costs • Step 2:

  12. Staffing costs for proposed model • Staff costs per centre/zone • 5.5 WTE band 6 • Capital costs per centre/zone • £269,032 • £175k (NRP) • £???k (NMP)

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