HAEMODYNAMICS OF MITRAL STENOSIS

1. HAEMODYNAMICS OF MITRAL STENOSIS DR VINOD G V

2. Normal MVA 4-5 cm2 • No pressure gradient across mitral valve during diastole Consequence of narrowed orifice 1.Development of pressure gradient across mitral valve 2.Progressive rise in LA pressure, pulmonary venous pressure 3.Dependence of LV filling on LA pressure 4.Reduction of blood flow across mitral valve

4. Torricelli's 2 Torricelli's 1 F=CO/HR xDFP

5. Factors affecting trans mitral gradient

6. Factors ↑ gradient • ↑ COP • Exertion ,emotion,high output states • ↓ DFP • Increase HR • ↓ MVA • Progression of disease • Factors decreasing gradient • ↓ COP • Second stenosis • RV failure • ↑ DFP • Slow HR • ↑ MVA

8. PAH in MS • Passive -Obligatory increase in response to increased LA pressure to maintain gradient of 10 to 12 across pulmonary vascular bed(PA mean- LA mean) • Reactive PA mean pressure –LA mean pressure >10 to 12 Pulmonary vasoconstriction • Obliterative changes in pulmonary arterioles Medial hypertrophy Intimal proliferation

9. Causes of reactive pulmonary HTN • Wood-pulmonary vasoconstriction • Doyle-↑pulmonary venous pressure prominent in the lower lobes, produce reflex arterial constriction • Heath &Harris-↑ PA pressure causes reflex arteriolar constriction

10. Jordan- • ↑pulmonary venous pressure-transudation of fluid • causes thickening and fibrosis of alveolar walls • hypoventilation of lower lobes-hypoxemia in lower lobe vessels • Sensed by chemoreceptors in pulmonary veins • Pulmonary arteriolar vasoconstriction in regions supplying these alveoli • Lower lobe perfusion decreases • This process eventually involve middle and upper lobe

11. Second Stenosis

12. Stage 1 • Asymptomatic at rest • Stage 2 • Symptomatic due to elevated LA pressure • Normal pulmonary vascular resistance • Stage 3 • Increased pulmonary vascular resistance • symptoms of low COP • Stage 4 • Both stenosis severe • Extreme elevation of PVR-RV failure

14. Consequence of PAH: • RVH,TR • Reduced CO • Elevated pre capillary resistance protects against development of pulmonary congestion at cost of a reduced CO • Severe pulmonary HTN leads to right sided failure

15. Effect of AF • ↑HR,↓DFP-elevates trans mitral gradient • Can result in acute pulmonary edema • Loss of atrial contribution to LV filling • Normal contribution of LA contraction to LV filling 15% • In MS, increases up to 25-30% • Lost in AF

16. Calculation of MVA Gorlin’s formula

17. Flow • Total cardiac output divided by time in seconds during which flow occurs across the valve • F=COP/DFPXHR

18. Steps in calculating MVA • Average gradient=area(mm2)/length of diastole(mm) • Mean gradient=average gradient X scale factor • Average diastolic period=length of DFP(mm)/paper speed(mm/s) • HR(beat/min), COP(ml/min) • MVA=cardiac output/HR × average diastolic periodperiod÷37.7×√mean gradient

21. Pitfalls in calculating MVA • Overestimation of trans mitral gradient occurs when PCWP is not taken properly • Failure to wedge properly cause one to compare damped pulmonary artery pressure to LV pressure • To ensure proper wedging -mean wedge pressure is lower than mean PA pressure -Blood withdrawn from wedge catheter is >95% saturated

22. Alignment Mismatch • Alignment of the PCW and LV pressure tracings does not match alignment of simultaneous LA and LV tracings • There is a time delay of 50-70msec • V wave in LA pressure tracing peaks immediately before LV pressure down stroke • Realign wedge tracing so that the V wave peak is bisected by or slightly to the left of the down stroke of LV pressure

24. CO determination • Simultaneous measurement with LA-LV pressure tracing • Under estimation of valve area in case of associated MR • Thermo dilution method inaccurate when associated TR

25. Damped PCW-LV Vs LA-LV Overestimation of MVG occur if damped PCW P is used

26. LA-LV gradient in AF • With long diastolic filling period ,progressive decrease in LA pressure • Increase with short diastole • Measure gradient in 3 to 4 diastolic complexes with nearly equal cycle length and measure the mean value

28. Symptoms and signs Hemodynamic correlation

29. Acute pulmonary edema • Increased pulmonary venous pressure • Increased transudation of fluid • Decreased lymphatic clearance • Pulmonary capillary pressure exceeds tissue oncotic pressure of 25mm Hg

30. Hemoptysis • Pulmonary apoplexy -rapture of bronchial vein -massive hemoptysis • Pink frothy sputum during pulmonary edema • Chronic bronchitis • Pulmonary infarction

31. Loud S1 • Rapidity with which LV pressure rises when mitral valve closes • Mitral valve closes at higher dp/dt of LV • Wide closing excursion of valve leaflets

33. A2-OS interval • OS occurs due to sudden tensing of valve leaflets after the valve cusps have completed their opening excursion • Follows A2 by 40-120msec • Interval varies inversely with LA pressure • Shorter A2-OS interval indicates severe MS

34. Diastolic murmur • Mid diastolic component starts with OS • Holo diastolic in severe MS due to persistent gradient • Presystolic component: -Atrial contraction -Persistent LA-LV pressure gradient - can persists even in AF

35. Doppler ECHO • Rate of fall in flow velocity is slow • No period of diastasis • Increased early diastolic peak velocity

36. Mitral Pressure Half Time • The pressure halftime is defined as the time required for the pressure to decay to half its original value • Mitral valve area (MVA) calculated as: MVA = 220/PHT • Not affected by CO,MR • PHT =11 .6xCnx√ MPG/(CcxMVA) • Cn-net compliance

37. Disadvantage • Poor ventricular compliance will increase the rate of pressure rise in diastole • Shorten PHT overestimate MVA • Significant AR, diastolic dysfunction alter PHT • Post BMV PHT is inaccurate

38. Q1 • O2 consumption 180 ml/min • A-V O2 difference 40 ml/L • HR 76/min SR • LV diastolic mean 6 • Diastolic filling period 0.42 sec/beat • PCW mean 24 • PA 40/22 -mean 22

39. Q2 • Body surface area 1.4 m2 • O2 consumption 201ml/min • A-V O2 difference 110 mL/L • PR 92/min • LV diastolic mean 10 • Diastolic filling period 0.36sec/beat • PCW mean 33 • PA 125/65, mean 75