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Nucleus

Mesoporous Silica Nanoparticle (MSN). Endosome. Mammalian cell. During the formation of the endosome (vesicle containing the up taken MSN) a layer of protein (clathrin) forms around it. Click to continue. Surface functional group for recognition or control of cellular uptake of MSN.

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Nucleus

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  1. Mesoporous Silica Nanoparticle (MSN) Endosome Mammalian cell During the formation of the endosome (vesicle containing the up taken MSN) a layer of protein (clathrin) forms around it. Click to continue. Surface functional group for recognition or control of cellular uptake of MSN. Drug or biomolecule to be delivered by the MSN. Removable cap to enable control over the release of loaded molecules. Click the slide to observe an animation describing the drug/biomolecule delivery by MSN. Nucleus Finally, a specific stimulus, which depends on the chemistry employed in the design of the composite, triggers the removal of the caps and the pre-loaded drugs or biomolecules are able to diffuse into the cytoplasm. Later on, probably because of the buffering capacity of its silanol groups, the MSN is able to escape from the endosome. Click to continue. The MSN is endocytosed by the cell with an efficiency that is dependent on the surface charge and the nature of the functional groups in their surface. Click to continue.

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