Molecular Characterization of Dissolved Pyrogenic Carbon by Ultrahigh Resolution Mass Spectrometry

Sep 16, 2012

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Molecular Characterization of Dissolved Pyrogenic Carbon by Ultrahigh Resolution Mass Spectrometry

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Mass Spectrometry

Mass Spectrometry Chapter 14 Chapter 14 Mass Spectrometry (MS) An analytical technique for measuring the mass-to-charge ratio ( m/z ) of ions in the gas phase. Mass spectrometry is our most valuable analytical tool for determining accurate molecular masses.

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Mass Spectrometry

Mass Spectrometry. Introduction General overview Mass Spectrometry is the generation, separation and characterization of gas phase ions according to their relative mass as a function of charge

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Mass Spectrometry. 2012 Fall version dslee@swu.ac.kr. Basic theory of mass spectrometry

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Protein misfolding characterization by ion mobility-mass spectrometry (IM-MS)

Paper 1: Bleiholder C., Dupuis N F., Wyttenbach T. & Bowers, M.T. Ion mobility-mass spectrometry reveals a conformational conversion from random assembly to b - sheet in amyloid fibril formation. Nat. Chem. 3, 172-177 (2010)

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Mass Spectrometry

2012 Student Practice in JINR Fields of Research 1.oct.2012. Mass Spectrometry. Brief introduction (part1). I. Sivacek flerovlab.jinr.ru. Mass spectrometer. Ion source – analyzing magnet – detector (basic setup) Isotope identification Molecule identification

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Mass Spectrometry

Mass Spectrometry. Kyle Chau and Andrew Gioe. Computation of Molecular Mass. Mass Spectrum is a plot of intensity as a function of mass-charge ratio, m/z. Mass-charge ratio can be determined through accelerating an ion. Conti.

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Mass Spectrometry

Mass Spectrometry . David Graham, Ph.D. dgraham@jhmi.edu Jennifer Van Eyk , Ph.D. jvaneyk1@ jhmi.edu. Lab Goals. Familiarization with how to manipulate finished data sets and extract biological meaning Familiarization with some of the bioinformatics tools

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Mass Spectrometry

Mass Spectrometry. Andrew Rouff and Ben Berger. A Brief History. 1897- JJ Thomson recorded first mass-to-charge ratio of electrons 1951- W. Pauli and H. Steinwedel developed first quadrupole mass spectrometer 1959- K. Biemann applies electron ionisation mass spectrometry

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Mass Spectrometry

Mass Spectrometry. Mass Spectrum of Benzene. Mass Spectrum of Benzene. Block Diagram. Sample Introduction. 1. Direct Insertion 2. Electron Ionization 3. Chemical Ionization 4. Electrospray Ionization 5. Laser Desorption 6. Fast Atom Bombardment. 1. Direct Insertion.

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Determination of molecular structure of isomers by Mass Spectrometry

Determination of molecular structure of isomers by Mass Spectrometry. YKO9030 Spektroskoopia erikursus 04. April 2014 Maksim Osheka. Isomerism. Differentiation of Diastereoisomers by Mass Spectrometry and Density Functional Theory. MS: EI-DF

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Mass Spectrometry

Mass Spectrometry. Week 2 Lab S117 Fall 2011. Overview. Post-Lab: Percent Alcohol in Wine TurnItIn.com Working with data sets Analyzing data sets Analysis of experimental procedure Pre-lab: Mass Spectroscopy Fragmentation Protein Analysis Practical matters of lab meeting.

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Mass Spectrometry

Mass Spectrometry. Relative atomic masses and the mass of individual isotopes can be determined using a mass spectrometer.

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Mass Spectrometry

Mass Spectrometry. Hyphenated Techniques GC-MS LC-MS and MS-MS. Reasons for Using Chromatography with MS. Mixture analysis by MS alone is difficult Fragmentation from ionization (EI or CI) Fragments from each component in one spectrum yields intractable interpretation

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Mass Spectrometry

Mass Spectrometry. Mass Spectrometry. Principles Mass Spectra. http://www.mrc-dunn.cam.ac.uk/facilities/mass_spectrometry.php. Principles. The study of ionised molecules in the gas phase Principles date back to ~ 1897 Based on accelerating ions in a vacuum

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Mass spectrometry

Mass spectrometry. Detection of ionic species to determine the molecular weight of and obtain structural information on a molecule. Mass spectrometry. ions only detected individual molecules are detected uses isotopic masses not MW. 29. Base Peak. Parent ion. -15. Base peak

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Mass Spectrometry

Mass Spectrometry. The substance being analyzed (solid or liquid) is injected into the mass spectrometer and vaporized at elevated temperature and reduced pressure. The gaseous molecules are bombarded with high-energy electrons, which

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Mass Spectrometry. Mass Spectrometry. Used to identify organic compounds mainly through molar mass and identification of major fragments. A mass spectrometer is often used as the “detector” for a gas chromatograph (GC-MS)

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Mass Spectrometry

Mass Spectrometry. Reading EI Spectra: Recognition of M + Deduction of Formula (3) Fragmentation of M +. Recognition of Molecular Ion. Is h ighest m/z value even? If odd then what? Do highest m/z fragments make sense? M-15 present? M-18? M-31? M-29? M-3  M-14 are impossible

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Characterization of Recombinant Glycoprotein by Mass Spectrometry

Characterization of Recombinant Glycoprotein by Mass Spectrometry. Min Xie Spring, 2001. Introduction. Glycosylation is the most common and versatile post-translational modification in high organisms, carbohydrates covalently bind to polypeptide backbones.

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Mass Spectrometry

Mass Spectrometry. From here…. To here!. Molecular Weight: 70 amu Molecular Formula: C 5 H 10. Detection of ionic species to determine the molecular weight of and obtain structural information on a molecule. Mass spectrometry. Fig. 12-1, p. 410. Gas Chromatography –

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Mass Spectrometry

Mass Spectrometry. WEB resources: http://www.colby.edu/chemistry/OChem/DEMOS/MassSpec.html http://www-methods.ch.cam.ac.uk/meth/ms/theory/index.html. Ionization. Electron. separate m/z. ionize. Fast Atom Bombardment. Plasma Desorption. Ionization. Thermospray. Electrospray. +. -. -.

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Molecular Mass Spectrometry

Molecular Mass Spectrometry. Prof. N. Rama Rao Chalapathi Institute of Pharmaceutical sciences, Guntur nadendla2000@yahoo.co.in. 44amu. 44amu. +1. +2. =. =. 44. mass (amu or dalton). charge(+). =. =. 22. m. m. z. z. I. Introduction.

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