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Getting ready to submit an R series grant application

Getting ready to submit an R series grant application. Choosing the right funding mechanism. R01: Research Project Grant.

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Getting ready to submit an R series grant application

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  1. Getting ready to submit an R series grant application Choosing the right funding mechanism

  2. R01: Research Project Grant • Definition:“Supports discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing the investigator's specific interest and competencies, based on the mission of the NIH.” • Funding • Up to 5 years • Most R01s use “modular budgets” ($250K/year or less in direct costs) • Special permission is required to submit an R01 if any year exceeds $500K/year in direct costs.

  3. Transitioning from a K award to an R01 Address a clearly defined problem • Focus, focus, focus: Remember, the R01 should be a “discrete, specified, circumscribed project.” Build on previous research • Published manuscripts of original research on the topic of the R01 are critical. • Remember, the intent of the K award is to provide you with the track record you will need to compete successfully for an R01. • Even if you are changing directions from your K award research plan, you need to anticipate the operational research challenges of the R01 project you intend to propose and to acquire the relevant expertise during your K award.

  4. Transitioning from a K award to an R01 • Propose a scope of work that is appropriate to the track record of the investigator • Preliminary studies provide the evidence of your competence to accomplish the scope of work you propose in your R01. • Published vs. unpublished studies. • Scientific findings vs. evidence of operational competence • Beware of proposing “an overly ambitious research plan.” • By proposing a more modest scope of work, you minimize your vulnerability in review while maximizing your ability to do an outstanding job on all aspects of the proposed research. • See Examples 1 and 2

  5. R03: Small Grant • Definition: Supports small projects that can be carried out in a short period of time with limited resources. • Funding: Up to $100K in direct costs for 2 years ($50K/year) • Appropriate projects • Pilot or feasibility studies • Secondary analysis of existing data • Small, self-contained research projects • Development of research methodology or new research technology

  6. R21: Exploratory/Developmental Grant • Definition: Provides support for the early or conceptual stages of development. • Funding: Up to $275K in direct costs over 2 – 3 years. • Appropriate projects: Should address the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. • The NIH parent announcement describes this research as “High Risk – High Impact.” • However, some Institute-specific program announcements may not emphasize this requirement. • Warning! Not all NIH institutes support R21s!

  7. Transitioning from a K award to an R03 or an R21 • Build on previous research • By building on the accomplishments of your K award, you establish a track record for the R03 or R21, which then could provide the track record for a subsequent R01. • Propose an appropriate scope of research • Be mindful of modest resources provided by these mechanisms. • See Examples 3 and 4

  8. The Multiple PI/PD Option If you lack key competencies with regard to the approach you’re proposing in the R01, you might consider the “multiple PI/PD” option. • This option should be used only in circumstances where “team science” is employed. • These projects require 2 or more equally important areas of expertise that would normally not be found in a single investigator. • Recruit a senior investigator whose expertise complements yours and addresses critical competencies that you lack.

  9. 3 Examples • A geneticist (K scholar) teams with a specialist in cancer pain (a senior investigator) to investigate genetic aspects of symptoms relevant to cancer pain. • A ob-gyn (K scholar) teams with a psychologist (a senior investigator) to evaluate a behavioral intervention to reduce unwanted weight gain during pregnancy. • A nephrologist with expertise in acute kidney injury (K scholar) teams with a nephrologist with expertise in chronic kidney disease (a senior investigator) to examine the role of biomarkers used in acute kidney disease to understand progression of chronic kidney disease and response to treatment.

  10. Homework • Be prepared to describe a potential research project (an R01, R03, or R21) that meets the following criteria: • Meets an institute funding priority, if possible. • Addresses a relevant PA, PAR, RFA. • Meets all 3 “grant writing strategies that work.” • Addresses a clearly defined problem • Builds on previous research • Propose an appropriate scope of work

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