1 / 36

Cell Biology 13 - cytoskeleton 3 rd

Cell Biology 13 - cytoskeleton 3 rd. Sung Youn Lee, PhD. Student Veterinary collage, Room 320 02 450 3719, 016 293 6059 leevet@paran.com. Spectrin Membrane Skeleton.

michi
Download Presentation

Cell Biology 13 - cytoskeleton 3 rd

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Cell Biology 13- cytoskeleton 3rd Sung Youn Lee, PhD. Student Veterinary collage, Room 320 02 450 3719, 016 293 6059 leevet@paran.com

  2. Spectrin Membrane Skeleton The walls of mature red blood cells are made tough and flexible because of skeletal proteins like spectrin and actin, which form a network with the aid of protein 4.1.

  3. Biconcave shape

  4. Intermediate filament • Diameter : 10nm • Thickness : microfilament < Intermediate filament < microtubule • To provide resistance to mechanical stress placed upon the cell • Composed of heterogeous group of proteins • Microfilament ; actin • Microtubule ; tubulin • Intermediate filament ; several proteins

  5. IF monomer Parallel dimer Two dimer forms antiparallel tetramer Two dimer forms antiparallel tetramer  staggered 8 tetramer  protofilament Intermediate filament -rope like structure

  6. GFAP

  7. GFAP- Rat HippocampusTrimethyl Tin Intoxication

  8. Microtubules • are straight, hollow cylinders • have a diameter of about 25 nm • are variable in length but can grow 1000 times as long as they are thick • are built by the assembly of dimers of alpha tubulin and beta tubulin. • are found in both animal and plant cells

  9. Microtubules • [Function] • Ciliary and flagella motility • mitotic and meiotic chromo- • somal movements • intracellular vesicle transport • secretion • other processes

  10. Tubulin • Drugs have effect on tubulin • Colchicine • Vinblastin sulfate • Nocodazole • Paclitaxel(Taxol) Disrupt the nomal dynamic behavior of microtubule Cell vidision ▽ Anti-cancer drug

  11. GTP assembling GDP disassembling

  12. The neuronal cytoskeleton • Polymorphism • Directional flow of information

  13. The shape of neurons is determined by their cytoskeleton • EM-neuronal cytoplasm is filled with cytoskeletal structure. • Axial plane : 1st microtubule, 2nd neurofilament, 3rd actin microfilament – at the tip • Cytoskeletal structure plays important role in constructing the unique neuronal morphology.

  14. Neuronal metabolism requires stable and dynamically unstable filamentous structure • Neurons elongate and retract their process and can change their patterns of connectivity throughout life. • This is made possible by the existence of actin and tubulin in both a monomeric and polymeric state within neurons.

  15. Fast axonal transport is a major form of motility for secretory and membranous components • Average rate ; 250~400mm/day • Membrane associated • Plasmalema (proteins, cholesterol, phospholipids, gangliosides), synaptic vescle (neurotranmitters, neuropeptides, and enzymes), and mitochodria (50mm/day)

  16. Movement of the cytosol occurs by slow axonal transport • Average rate ; 1mm/day • Fibrillar elements in the cytoskeleton

  17. Thank you for your attention ~

More Related