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Clinical Research Sample Terminology (CReST) Affinity Group Update. Davera Gabriel, UC Davis Kristi Eckerson, Emory University. CReST Goals. Initial work to focus on human biospecimens Animal, microbial & environmental in future Development use cases & requirements
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Clinical Research Sample Terminology (CReST) Affinity Group Update Davera Gabriel, UC Davis Kristi Eckerson, Emory University
CReST Goals • Initial work to focus on human biospecimens • Animal, microbial & environmental in future • Development use cases & requirements • supports data-sharing, research repositories • Development of standards-based, common semantics • Common domain model • Terminology model • Development of sample content for use by CTSA IKFC organizations • Value Sets
CReST Process & Approach • Review relevant reference content • data standards, terminologies, coding systems… • Review current implementations to develop requirements, use cases • Include biobanking • Validate model & value set content through use by CTSA orgs
CReST progress to-date • Use case development • Validating at member organizations • Domain model review • Limit to samples • Add biobanking attributes • Value set development • Established standards • Implemented systems
CReST ‘Atomic’ Use Cases • Samples obtained, measured, discarded • Results recorded • Samples obtained, measured, banked • + storage information • Samples obtained, alloquots created, tracked in multiple locations • + multiple results, locations
Gender / Sex Species Units of Measure Blood Type Race Ethnicity Anatomic Location Sample Types Sample Container Collection Method Sample Additives Sample Source Test Codes Out of scope: Antigen expression (outside of blood type) Transplant requirements Cell line Microbial domain CReST Value Sets
CReST Participants • Jonas Almeida, UAB • Mathias Brochhausen, UAMS • Kristi Eckerson, Emory • Helena Ellis, Duke • Davera Gabriel, UC Davis • Carol Hill, Duke • Aenoch Lynn, Duke • Bernie LaSalle, U Utah • Salvadore Mungal, Duke • Anita Walden, Duke
CReST Participation • Weekly Teleconferences • Thursdays: 4p Eastern, 1p Pacific • Asynchronous contributions • Use Case Authoring, Validation • Biobanking • Implemented Standards • LIMS, Biobanking, sample management… • Implemented Value Sets • Identified Sample classes
Questions&Discussion Thank-you!