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Why use The Great Plains Laboratory?

The Great Plains Laboratory has performed more than 100,000 tests of persons on the autistic spectrum throughout the world. Free consultation with testing by phone/Skype 2 autistic children of Great Plains employees have completely recovered using suggestions of Great Plains

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Why use The Great Plains Laboratory?

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  1. The Great Plains Laboratory has performed more than 100,000 tests of persons on the autistic spectrum throughout the world. Free consultation with testing by phone/Skype 2 autistic children of Great Plains employees have completely recovered using suggestions of Great Plains Licensed by the USA government Performs external proficiency testing for all substances for which it does testing, including many of which are voluntary Great customer service by highly experienced staff. Why use The Great Plains Laboratory?

  2. Contact The Great Plains Laboratory by phone, fax, or email Phone 1 913 341-8949 Fax 1 913 341-6207 Email: gpl4u@aol.com Videos on how to prepare the test samples on the website at www.greatplainslaboratory.com How to obtain test kits

  3. Contain all necessary containers to transport samples Contains information to ship by FEDEX Contains all necessary information to ship samples Contains payment information, MasterCard, Visa, or electronic bank transfer Test kits

  4. Yeast/FungalMetabolites-no BacterialMetabolites-no B-vitaminDeficiencies-no AntioxidantDeficiencies-no InbornErrors of Metabolism HighOxalateLevels-no ORGANIC ACID TEST-Great Plains 72 Compounds and ratios • Neurotransmittermetabolism-no • Indications of diabeticconditions • Citricacid (Krebs) cyclemetabolites • Fattyacidabnormalities • Clostridiaovergrowth-no • Glycolysismetabolites • Amino Acidmetabolites • Pyrimidines-no • 72 compounds total

  5. Specific autism markers present on The Great Plains Laboratory Organic Acid Test

  6. Normal intestine Blood vessel * Y * B B B B B * B B B B B B Rest of body B B B * Intestine B * B Kidney B B B Y = yeast B B B Y * = yeast product B B B = good bacteria B Urine cup =bad bacteria B B * B

  7. After antibiotics **** **** **** **** ** ** ** ** ***** Blood vessel * * * ** ***** * ***** * ** * ****** * * * * ***** ** ******* Y ***** * * * Y * * * * * * * B Y * ***** * * Y * * * Rest of body * B* * * * Intestine Y * * * * Kidney *** * * Y * * **** * Y = yeast * * *Y * = yeast product ** * Y B = good bacteria * Urine cup **** *** * =bad bacteria Y * * * * * * ** ***** *****

  8. Nutritional Neuroscience 2010 Vol 13 No 3: 1-10

  9. Shaw, W Increased Urinary Excretion of Analogs of Krebs Cycle Metabolites and Arabinose in Two Brothers with Autistic Features. ClinChem 41:1094-1104, 1995 HPHPA

  10. Clostridia species that produce HPHPA precursors Arch Microbiol 1976; 107:283–288 • C. mangenoti • C. ghoni • C. bifermentans • C. caloritolerans • C. difficile-pseudomenbranous colitis • C. sporogenes • C. botulinum-food poisoning

  11. Two months of nystatin and Lactobacillus acidophilus GG therapy in a child with autism

  12. CH2CHCOOH NH2 CH2CHCOOH HO NH2 CH2CHCOOH CHCH2NH2 CH2CH2NH2 HO HO HO NH2 CH2CH2NH2 HO phenylalanine hydroxylase phenylalanine 3-hydroxyphenylalanine tyrosine hydroxylase Clostridia DOPA analog tyrosine HO DOPA decarboxylase HO DOPA Clostridia dopamine analog VMA OH X HVA Dopamine beta-hydroxylase HO HO Dopamine Norepinephrine

  13. Altered dopamine/norepinephrine ratio with Clostridia excess Dopamine Norepi, Epi HVA/VMA= 5:1 Dopamine/ Norepi, Epi

  14. Before treatment (depression) HVA/VMA= 2.58 (Excess dopamine)

  15. After treatment HVA/VMA= 1.38

  16. J Child Neurol 2000 Jul;15(7):429-35  Short-term benefit from oral vancomycin treatment of regressive-onset autism.  Sandler RH, Finegold SM, Bolte ER, Buchanan CP, Maxwell AP, Vaisanen ML, Nelson,MN, Wexler HM • 11 children with regressive-onset autism were recruited for an intervention trial using vancomycin. • A clinical psychologist blinded to treatment status..noted improvement in 8 of 10 children studied. • “…these results indicate that a possible gut flora-brain connection warrants further investigation”

  17. Staghorn oxalate crystal in kidney

  18. Comparison of urine oxalate in autistic spectrum and normal children t-test p <10-16 Autistic Spectrum N=100 Normal Children N=16

  19. Maternal Residence Near Agricultural Pesticide Applications and Autism Spectrum Disorders among Children in the California Central Valley Eric M. Roberts, et al. Environ Health Perspect. 115(10): 1482–1489, 2007 • Children exposed to pesticides called organophosphates used to kill insects had more than twice the risk of developing pervasive developmental disorder (PDD) • For organochlorines, there was 7X autism rate • Mothers exposed to such pesticides were also likely to have shorter pregnancies and their children to have impaired reflexes

  20. Mothers exposed to pet shampoos (almost all pyrethrins) were twice as likely to have a child with autism. The worst exposure time was the second trimester. I. Hertz-Picciotto, et al Public Health Sciences and the M.I.N.D. Institute, University of California at Davis, International Meeting for Autism Research (IMFAR) Household Pesticide Use in Relation to Autism, May 2008

  21. Abnormal peptides in both patients with autism and schizophrenia High titers of IgG antibodies to gliadin (wheat) found in 87% of patients with autism and 86% of patients with schizophrenia High titers of IgG antibodies to bovine casein found in 90% of patients with autism and 93% of patients with schizophrenia A gluten and casein free diet caused significant improvement in 81% of patients with autism within 3 months R Cade et al. Autism and schizophrenia: Intestinal disorders. Nutritional Neuroscience 3: 57-72,2000 Depts. of Medicine, Physiology, Psychology, and Psychiatry, University of Florida, USA

  22. Efficacy of a cow's milk free diet (or other foods which gave a positive result after a skin test) in 36 autistic patients. Marked improvement in the behavioral symptoms of patients after a period of 8 weeks on an elimination diet High levels of IgA antigen specific antibodies for casein, lactalbumin and beta-lactoglobulin High IgG and IgM for casein Lucarelli S, Panminerva Med 1995 Sep;37(3):137-41 Food allergy and infantile autism.

  23. Great Plains data normal autism

  24. IgG Comprehensive Food Allergy Test - Autism

  25. IgG antibody test • Blood draw • Fingerstick done home IgE antibody test • Blood draw only

  26. Great Plains Immune Deficiency Profile

  27. Great Plains Immune Deficiency Profile

  28. Great Plains Immune Deficiency Profile

  29. IgA deficiency Total IgG deficiency IgG subclass deficiency Complement C4b deficiency Myeloperoxidase deficiency Severe combined immunodeficiency disorder (SCID) Normal antibody concentrations but lack of specific antibodies, even though multiple vaccines given Immune deficiencies in autism

  30. Abnormally elevated IgE in child with autism and severe self abuse

  31. Autism and seizures

  32. Because of depression of cellular immunity, the person with autism becomes re-infected immediately after antifungal treatment stops Some parents report deterioration if even a single dose of antifungal drug is missed Some children on antifungals for over 10 years Recurrence of Candida: The most difficult medical problem in autism

  33. Streptococcus antibodies and autism-contribute to stereotypical behavior

  34. Throat rapid strep test Throat culture Cultures may give false negative results Group A beta-hemolytic streptococcus Antibodies may cause behavioral alteration even if strep organism is missing Prophylactic antibiotics Plasmapharesis and replacement Selective removal of plasma anti-strep antibodies IVIG-itravenous gamma globulin Streptococcus antibodies and autismfollowup

  35. Autism 9:290-298,2005 Hair metals in boys with autismn=40 boys per group, age matched

  36. “To Bind” from Greek word chele, or claw. Oral DMSA or TD-DMSA TD=transdermal Oral DMPS and/or TD-DMPS Oral EDTA and/or TD-EDTA Intravenous – DMPS, EDTA Suppository – Detoxamin (good for lead, aluminum) Natural Remedies – Chlorella, Cilantro, Homeopathic, etc. Sublingual vs Baths. Combination of different forms. Chelation Therapy Options

  37. Hair screen for long term exposure to toxic elements If all toxic elements are negative with hair metals, consider urine challenge test with DMSA,DMPS Evaluate copper/zinc balance with copper/zinc profile from Great Plains Use urine test (without challenge) to evaluate calcium levels Fecal metals can indicate oral exposure to metals especially lead but does not identify source Use X-ray fluorescence to determine sources of lead Whole blood or RBC good for acute toxicity Recommended testing summary

  38. Find and eliminate sources of toxicity Remove amalgams Control Candida since DMSA and DMPS stimulate Candida overgrowth Oral DMSA and DMPS cheap, safe, and effective but stimulate Candida and can make heavy metals worse if oral ingestion is still occurring. Extended treatment needed to remove toxic metals from brain Do periodic liver tests and blood counts Supplement with beneficial metals (Chelate-Mate®) Discontinue if tests abnormal or rare severe symptoms Recommended treatment

  39. Safety and Efficacy of Oral DMSA Therapy for Children with Autism Spectrum Disorders: Part B - Behavioral Results BMC Clinical Pharmacology 2009, 9:17 doi:10.1186/1472-6904-9-17 James B Adams (jim.adams@asu.edu) Matthew Baral (m.baral@scnm.edu) Elizabeth Geis (autismstudynurseasu@gmail.com) Jessica Mitchell (j.mitchell@scnm.edu) Julie Ingram (julieaingram@yahoo.com) Andrea Hensley (ahensley11@cox.net) Irene Zappia (izappia@aol.com) Sanford Newmark (snewmark@email.arizona.edu) Eva Gehn (egehn@asu.edu) Robert A Rubin (brubin698@earthlink.net) Ken Mitchell (kbmpd@yahoo.com) Jeff Bradstreet (drbradstreet@aol.com) Jane El-Dahr (jeldahr@tulane.edu)

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