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Imunidade Inata: Mecanismos Efetores

Departamento de Imunologia Instituto de Ciências Biomédicas Universidade de São Paulo. Imunidade Inata: Mecanismos Efetores. Dr. Antonio Condino Neto Professor Associado Livre-Docente. Figure 2-1. Imunidade Inata x Imunidade Adaptativa. Figure 2-2 part 1 of 2. Figure 2-2 part 2 of 2.

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Imunidade Inata: Mecanismos Efetores

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  1. Departamento de Imunologia Instituto de Ciências Biomédicas Universidade de São Paulo Imunidade Inata: Mecanismos Efetores Dr. Antonio Condino Neto Professor Associado Livre-Docente

  2. Figure 2-1 Imunidade Inata x Imunidade Adaptativa

  3. Figure 2-2 part 1 of 2

  4. Figure 2-2 part 2 of 2

  5. Figure 2-3 Exemplo de Resposta à Infecção

  6. Figure 2-4

  7. Figure 2-5 part 1 of 2

  8. Figure 2-5 part 2 of 2

  9. Figure 2-6 Fagocitose

  10. NADPH-Oxidase Adaptado de Curnutte et al, 2002

  11. Figure 2-8 part 1 of 2

  12. Figure 2-8 part 2 of 2

  13. Figure 2-9

  14. Figure 2-10

  15. Figure 2-11

  16. Figure 2-12

  17. TLR Ligands - Recognition PAMPS

  18. Figure 2-13

  19. TLR signal generation to NF-kB after ligation TLR 4 TLR 5/10/11 TLR 2 TLR 1/6 MD2 CD14 Cell membrane TIRAP TIRAP TLR 3 MyD88 TLR 7/8/9 MyD88 MyD88 Endosome IRAK4 TRIF TRAF6 RIP1 MyD88 NEMO p IKK- IKK- IkB IkB Cytoplasm NF-B New gene transcription Nucleus NF-B binding motif

  20. TLR induction of other transcription factors TLR 4 TLR 5/10/11 TLR 2 TLR 1/6 MD2 CD14 Cell membrane TIRAP TRAM TIRAP TLR 3 MyD88 TLR 7/8/9 TRIF MyD88 MyD88 Endosome TRIF IRAK4 MyD88 TRAF6 IRAK1/4 IRF5 TRAF6 IRF7 TBK1 MAPK IRF3 AP-1 Cytoplasm New gene transcription Nucleus

  21. Figure 2-15

  22. Figure 2-39

  23. Figure 2-41 part 1 of 2

  24. Figure 2-41 part 2 of 2

  25. Figure 2-45

  26. Figure 2-46

  27. Figure 2-47

  28. Figure 2-44

  29. Figure 2-42

  30. Figure 2-43

  31. (CD11a/CD18) Quimiotaxia de Neutrófilos LAD- I LAD- II E-Selectin Sialyl-Lewis-X Rolagem Adesão Emigração Transendotelial

  32. Lesão Cutânea em Paciente com LAD-I Leucócitos - 40.200 cels/mm3

  33. Figure 2-48

  34. Figure 2-49

  35. Figure 2-50

  36. Figure 2-52

  37. Figure 2-53

  38. Figure 2-20

  39. Figure 2-18

  40. Figure 2-19

  41. Figure 2-21

  42. Figure 2-24

  43. Figure 2-23

  44. Figure 2-27

  45. Figure 2-29

  46. Figure 2-34

  47. Figure 2-36

  48. Figure 2-31

  49. Figure 2-35

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