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Pathogenomics in Israel Eliora Z. Ron eliorapost.tau.ac.il

Facilities for pathogenomic studies. Good facilities for genomics, transcriptomics and proteomics in several universities and research institutesHigh level bioinformatics All facilities are also available as service. Metagenomics . Metagenomics of culturable and non-culturable microorganism popula

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Pathogenomics in Israel Eliora Z. Ron eliorapost.tau.ac.il

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    1. Pathogenomics in Israel Eliora Z. Ron <eliora@post.tau.ac.il> Metagenomics LGT = lateral gene transfer Typing of bacterial strains and drug resistance Identification of virulence factors Whole genome analysis

    2. Facilities for pathogenomic studies Good facilities for genomics, transcriptomics and proteomics in several universities and research institutes High level bioinformatics All facilities are also available as service

    3. Metagenomics Metagenomics of culturable and non-culturable microorganism populations present in biofilms of Acute Otitis Media (AOM, Middle Ear Infection) This infection involves a variety of bacterial species, found in the form of biofilms, which are inherently resistant to antibiotic treatment Detection of microbial biodiversity of AOM biofilm is limited due to current cultivation methods The group of Fauzi Silbaq (ArabQual) and Racheli Kreisberg-Zakarin (IBEX) racheli@ibexperts.com in involved in a study the biodiversity of AOM using a metagenomics approach, including microbiology, functional genomics and bioinformatics methodologies

    4. Metagenomics Metagenomics of intestinal microflora in health and disease and the effect of the TLR mutations Toll-Like Receptors (TLRs) recognize pathogen specific patterns of microorganisms. Mutations in TLRs are associated with inflammatory bowel diseases (Crohn's disease and ulcerative colitis). Patients with those diseases have altered intestinal microflora Uri Gophna, currently with Ford Doolitle in Halifax ugophna@dal.ca performs culture-independent profiling of intestinal microflora of TLR knockout mice under normal conditions and after a challenge which models inflammatory bowel disease

    5. LGT – lateral gene transfer in relation to pathogenesis Uri Gophna ugophna@dal.ca studies the role of lateral gene transfer (LGT) in the evolution of pathogens Uses bioinformatics for the identification of laterally acquired genes and pathways in pathogens

    6. Yair Aharonowitz, Ilya Borovok and Gerald Cohen from Tel Aviv University study gluthathione synthesis yaira@tauex.tau.ac.il Identified GshF orthologs, consisting of a ?-glutamylcysteine ligase (GshA) domain fused to an ATP-grasp domain, in 20 gram-positive and gram-negative bacteria. Remarkably, 95% of these bacteria are mammalian pathogens. Presumably, this fusion gene, once formed, spread between mammalian hosts most likely by horizontal gene transfer LGT – lateral gene transfer in relation to pathogenesis

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