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The Complement System. Ricklin and Lambris 2007. Functions of the Complement System. •Viral neutralization. The Complement System. Components of the Complement System: proteins and glycoproteins synthesized mainly by liver 5% of serum circulate as zymogens
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The Complement System Ricklin and Lambris 2007
Functions of the Complement System •Viral neutralization
The Complement System Components of the Complement System: proteins and glycoproteins synthesized mainly by liver 5% of serum circulate as zymogens Designation of complement components: numerals (C1-C9) letter symbols (factor D) trivial names (homologous restriction factor) cleavage products – “a” and “b”
Complement Activation Pathways Immunobiology (Garland Science 2005)
The Complement System Complement Activation:
The Complement System Classical Pathway requires antibody interaction:
Consequences of Complement Activation •The three complement pathways converge at the membrane-attack complex (MAC).
Regulation of the Complement System Regulation can occur at multiple steps in the complement system: Before assembly of convertase activity After assembly of convertase Assembly of membrane attack complex (MAC) Turnberg and Botto, 2003
Microbial Evasion •Some microbes can evade complement-mediated damage. Schneider, et al 2007