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COMPLEMENT SYSTEM

COMPLEMENT SYSTEM. CELLULAR IMMUNITY. Doç. Dr. Gülderen Yanıkkaya Demirel. WHAT YOU WILL LEARN TODAY. LYMPHOCYTE MATURATION THYMUS and T CELLS MHC – MAJOR HISTOCOMPATABILITY COMPLEX TCR AND MHC INERACTION. LYMPHOCYTE DIFFERENTIATION. Cell Mediated and Humoral Immunity.

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COMPLEMENT SYSTEM

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  1. COMPLEMENT SYSTEM

  2. CELLULAR IMMUNITY Doç. Dr. Gülderen Yanıkkaya Demirel

  3. WHAT YOU WILL LEARN TODAY • LYMPHOCYTE MATURATION • THYMUS and T CELLS • MHC – MAJOR HISTOCOMPATABILITY COMPLEX • TCR AND MHC INERACTION

  4. LYMPHOCYTE DIFFERENTIATION

  5. Cell Mediated and Humoral Immunity • Cell Mediated Immunity (Cellular Immunity), can be adoptively transferred only by viable T lymphocytes • Humoral immunity, can be adoptively transferred with serum containing antibodies.

  6. Cell Mediated Immunity • General responses by CMI, include: • Facilitate innate immune response to bacteria • Anti-viral • Anti-fungal • Anti-tumor • Transplantationrejection

  7. CELL PRODUCTION PATHWAYS

  8. Thymus Structure

  9. Apoptotic cells in red. • Macrophages in blue. ~ 98% of developing thymocytes undergo apoptosis.

  10. B LYMPHOCYTE

  11. B LYMPHOCYTE MATURATION

  12. T CELL MATURATION

  13. DN1 DN2 DN3 “Double negative” CD3- 4- 8- 1st rearrangement Kit+ DN4 1 week CD3+ T cell Progenitor enters outer cortex- does not express markers Pre-TCR CD4+8+ “Double Positive” 2nd rearrangement

  14. DN2 DN3

  15. CELL ACTIVATION

  16. MHC – MAJOR HISTOCOMPATABILITY COMPLEX

  17. MHC

  18. TCR

  19. AG PROCESSING

  20. AG PRESENTATION by MHC I

  21. ANTIGEN PRESENTATION BY MHC II

  22. CROSS PRESENTATION

  23. When the TCR finds MHC-Ag that is a fit the transient interaction becomes stabilized.

  24. To complete T cell activation, costimulatorysignals are required. 3

  25. CD28- on resting & activated T cells. • B7.1 & B7.2 on professional APC: • Dendritic cells • Activated macrophages & B cells. • Costimulatory signal & TCR interaction must be delivered by the same APC.

  26. ANTIBODY CHANGES

  27. DOMINANT EPITOPES

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