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Supplemental Figure 1.

Supplemental Figure 1. Codon L576P CTT →　 CCT. Wild type. Mutation. Supplemental Figure 2. DM440 DM366. nM. 0 10 100 1000. 0 10 100 1000. Src. p- Src. FAK. p-FAK. P130. p-P130. DM6 DM738. Actin. WM3211. nM.

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Supplemental Figure 1.

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  1. Supplemental Figure 1. Codon L576P CTT →　CCT Wild type Mutation

  2. Supplemental Figure 2. DM440 DM366 nM 0 10 100 1000 0 10 100 1000 Src p-Src FAK p-FAK P130 p-P130 DM6 DM738 Actin WM3211 nM 0 10 100 1000 0 10 100 1000 0 10 100 1000 Src p-Src FAK p-FAK P130 p-P130 Actin

  3. Supplemental Figure 3. % inhibition of cell proliferation with 1000nM dasatinib alone DM440 Src-predicted dysregulation

  4. Supplemental Figure 4. 1 2 3 4 5 6 7 8 Model number Harvest Model1 (Control) Src 0 4hr 8hr 16hr 24hr Dasatinib Harvest p-Src Model 2 FAK A Dasatinib Harvest p-FAK Model 3 P130 Dasatinib p-P130 Harvest Model 4 Actin Dasatinib Harvest Model 5 Dasatinib Dasatinib Harvest Model 6 Dasatinib Dasatinib Harvest B Model 7 Dasatinib Dasatinib Harvest Dasatinib Model 8

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