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Chapter 45: Hormones and the Endocrine System

}. Membrane bound. Chapter 45: Hormones and the Endocrine System. What is the difference between paracrine & endocrine? Paracrine – local signaling between neighboring cells Endocrine – distance signaling thereby using the circulatory system Review Ch 11: Cell communication Reception

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Chapter 45: Hormones and the Endocrine System

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  1. } Membrane bound Chapter 45: Hormones and the Endocrine System • What is the difference between paracrine & endocrine? • Paracrine – local signaling between neighboring cells • Endocrine – distance signaling thereby using the circulatory system • Review Ch 11: Cell communication • Reception • G protein-linked receptors • Tyrosine kinase receptors • Ion channel receptors • Steroid hormone receptors – intracellular • Transduction • 2nd messengers – Ca+2 ions, cAMP, IP3 & DAG • Phosphorylation cascades – protein kinases • Response • Gene activation aka transcription • Enzyme activation • Cell division

  2. SECRETORY CELL SECRETORY CELL Hormone molecule Hormone molecule VIA BLOOD VIA BLOOD Signal receptor TARGET CELL TARGET CELL Signal transduction pathway Signal receptor OR Cytoplasmic response DNA Signal transduction and response mRNA DNA NUCLEUS Nuclear response Synthesis of specific proteins NUCLEUS (b) Receptor in cell nucleus (a) Receptor in plasma membrane Figure 45.3 Mechanisms of hormonal signaling: a review

  3. Chapter 45: Hormones and the Endocrine System • What is the difference between paracrine & endocrine? • What are the 3 general types of signaling pathways? • Simple endocrine • Simple neurohormone • Simple neuroendocrine

  4. Pathway Example Pathway Example Example Pathway Low blood glucose Hypothalamic neurohormone released in response to neural and hormonal signals Stimulus Stimulus Suckling Stimulus Receptor protein Sensory neuron Sensory neuron Pancreas secretes glucagon ( ) Hypothalamus/ posterior pituitary Hypothalamus Endocrine cell Neurosecretory cell Blood vessel Neurosecretory cell Hypothalamus secretes prolactin- releasing hormone ( ) Posterior pituitary secretes oxytocin ( ) Blood vessel Blood vessel Target effectors Liver Anterior pituitary secretes prolactin ( ) Smooth muscle in breast Target effectors Glycogenbreakdown,glucose releaseinto blood Response Endocrine cell Blood vessel (a) Simple endocrine pathway Milk release Response (b) Simple neurohormone pathway Target effectors Mammary glands Milk production Response (c) Simple neuroendocrine pathway Figure 45.2 Basic patterns of simple hormonal control pathways

  5. Students • Staple corrections behind test • Place in box • Test – Thursday 2/23 • AP Exam info • Yes or No by 2/21 • Payment by 3/9.

  6. Chapter 45: Hormones and the Endocrine System • What is the difference between paracrine & endocrine? • What are the 3 general types of signaling pathways? • How can 1 ligand cause different effects? • Different receptor types on different cells • Different intracellular signal molecules

  7. Different receptors different cell responses Epinephrine Epinephrine Epinephrine b receptor a receptor b receptor Glycogendeposits Vessel dilates Vessel constricts Glycogen breaks down and glucose is released from cell (a) Intestinal blood vessel Skeletal muscle blood vessel (b) (c) Liver cell Different intracellular proteins different cell responses Figure 45.4 One chemical signal, different effects

  8. Hypothalamus Pineal gland Pituitary gland Thyroid gland Parathyroid glands Adrenal glands Pancreas Ovary (female) Testis (male) Figure 45.6 Human endocrine glands surveyed in this chapter

  9. Chapter 45: Hormones and the Endocrine System • What is the difference between paracrine & endocrine? • What are the 3 general types of signaling pathways? • How can 1 ligand cause different effects? • What are some common endocrine glands? • How does the hypothalamus control the anterior & posterior pituitary • differently? • - posterior – directly via neurohormones • - anterior – indirectly via releasing hormones (tropic hormones)

  10. Hypothalamus Neurosecretory cells of the hypothalamus Axon Posterior pituitary Anterior pituitary ADH HORMONE Oxytocin Mammary glands, uterine muscles TARGET Kidney tubules Figure 45.7 Production and release of posterior pituitary hormones

  11. Tropic Effects Only FSH, follicle-stimulating hormone LH, luteinizing hormone TSH, thyroid-stimulating hormone ACTH, adrenocorticotropic hormone Nontropic Effects Only Prolactin MSH, melanocyte-stimulating hormone Endorphin Nontropic and Tropic Effects Growth hormone Neurosecretory cells of the hypothalamus Portal vessels Hypothalamic releasing hormones (red dots) Endocrine cells of the anterior pituitary Pituitary hormones(blue dots) Endorphin FSH and LH TSH MSH HORMONE ACTH Prolactin Growth hormone Bones Mammary glands Testes or ovaries Melanocytes Liver Pain receptors in the brain Thyroid Adrenal cortex TARGET Figure 45.8 Production and release of anterior pituitary hormones

  12. Chapter 45: Hormones and the Endocrine System • What is the difference between paracrine & endocrine? • What are the 3 general types of signaling pathways? • How can 1 ligand cause different effects? • What are some common endocrine glands? • How does the hypothalamus control the anterior & posterior pituitary • differently? • How is the thyroid regulated? • Regulates metabolism • T3 & T4 hormones • Triiodothyronine (T3) & thyroxine (T4) have 3 or 4 iodine atoms

  13. Hypothalamus Anterior pituitary TSH Thyroid T3 T4 + Figure 45.9 Feedback regulation of T3 and T4 secretion from the thyroid gland TRH What happens with a lack of iodine in the diet? Pg 33

  14. Chapter 45: Hormones and the Endocrine System • What is the difference between paracrine & endocrine? • What are the 3 general types of signaling pathways? • How can 1 ligand cause different effects? • What are some common endocrine glands? • How does the hypothalamus control the anterior & posterior pituitary • differently? • How is the thyroid regulated? • How is homeostasis of blood calcium achieved? • - Thyroid & parathyroid glands

  15. Calcitonin Thyroid gland releases calcitonin. Reduces Ca2+ uptake in kidneys Stimulates Ca2+ deposition in bones Blood Ca2+ level declines to set point STIMULUS: Rising blood Ca2+ level Homeostasis: Blood Ca2+ level (about 10 mg/100 mL) STIMULUS: Falling blood Ca2+ level Blood Ca2+ level rises to set point Stimulates Ca2+ release from bones Parathyroid gland PTH Increases Ca2+ uptake in intestines Stimulates Ca2+ uptake in kidneys Active vitamin D Figure 45.11 Hormonal control of calcium homeostasis in mammals

  16. Chapter 45: Hormones and the Endocrine System • What is the difference between paracrine & endocrine? • What are the 3 general types of signaling pathways? • How can 1 ligand cause different effects? • What are some common endocrine glands? • How does the hypothalamus control the anterior & posterior pituitary • differently? • How is the thyroid regulated? • How is homeostasis of blood calcium achieved? • How is homeostasis of blood glucose achieved? • - Insulin and glucagon

  17. Body cells take up more glucose. Insulin Beta cells of pancreas are stimulated to release insulin into the blood. Liver takes up glucose and stores it as glycogen. STIMULUS: Rising blood glucose level (for instance, after eating a carbohydrate- rich meal) Blood glucose level declines to set point; stimulus for insulin release diminishes. Homeostasis: Blood glucose level (about 90 mg/100 mL) Blood glucose level rises to set point; stimulus for glucagon release diminishes. STIMULUS: Dropping blood glucose level (for instance, after skipping a meal) Alpha cells of pancreas are stimulated to release glucagon into the blood. Liver breaks down glycogen and releases glucose into blood. Glucagon Figure 45.12 Maintenance of glucose homeostasis by insulin and glucagon

  18. Chapter 45: Hormones and the Endocrine System • What is the difference between paracrine & endocrine? • What are the 3 general types of signaling pathways? • How can 1 ligand cause different effects? • What are some common endocrine glands? • How does the hypothalamus control the anterior & posterior pituitary • differently? • How is the thyroid regulated? • How is homeostasis of blood calcium achieved? • How is homeostasis of blood glucose achieved? • How does the body respond to short-term stress, ie fight or flight? • - epinephrine & norepinephrine

  19. Stress Nerve signals Hypothalamus Spinal cord (cross section) Releasing hormone Nerve cell Anterior pituitary Blood vessel Adrenal medulla secretes epinephrine and norepinephrine. Nerve cell Adrenal cortex secretes mineralocorticoids and glucocorticoids. ACTH Adrenal gland Kidney (a) Short-term stress response (b) Long-term stress response Effects of glucocorticoids: Effects of mineralocorticoids: Effects of epinephrine and norepinephrine: 1. Glycogen broken down to glucose; increased blood glucose Proteins and fats broken down and converted to glucose, leading to increased blood glucose 1. Retention of sodium ions and water by kidneys 1. 2. Increased blood pressure 3. Increased breathing rate 4. Increased metabolic rate 2. Increased blood volume and blood pressure 5. Change in blood flow patterns, leading to increased alertness and decreased digestive and kidney activity 2. Immune system may be suppressed Figure 45.13 Stress and the adrenal gland

  20. Table 45.1 Major Human Endocrine Glands and Some of Their Hormones

  21. Table 45.1

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