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Chapter 45: Hormones and the Endocrine System. By: Taylor Schwanzer. What is the Endocrine System?. Hormone - Secreted chemicals that are formed in specialized cells, travel in body fluids, and act on specific target cells in other parts of the body to change their functioning
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Chapter 45:Hormones and the Endocrine System By: Taylor Schwanzer
What is the Endocrine System? • Hormone - Secreted chemicals that are formed in specialized cells, travel in body fluids, and act on specific target cells in other parts of the body to change their functioning • Endocrine System - The internal system of communication involving hormones, the ductless glands that secrete hormones, and the molecular receptors on or in target cells that respond to hormones • Target Cells are those cells equipped to respond to hormones • Endocrine glands which are hormone-secreting organs • Neurosecretory cells secrete hormones into the blood
Signaling Molecules • Hormones: send regulatory messages throughout the body in extracellular fluid • Endocrine signaling • Local Regulators - cells adjacent to or near point of secretion • Neurotransmitters • Cytokines and growth factors • Nitric oxide • Prostaglandins - help regulate the aggregation of platelets • Paracrine Signaling • Autocrine Signaling • Neurotransmitters and Neurohormones • Neuroendocrine Signaling • Synaptic Signaling • Pheromones
Cellular Response Pathways • Water-Soluble Hormones • Lipid-Soluble Hormones • Multiple Effects of Hormones on target cells that have: • Different receptors for the hormone • Different signal transduction pathways • Different proteins for carrying out the response
Simple Hormone Pathways Simple Endocrine Pathway • Insulin and Glucagon: Control of Blood Glucose • Diabetes Mellitus • Type 1 (Insulin-Dependent) • Type 2 (Non-Insulin-Dependent) Positive Feedback
Coordination of the Endocrine and Nervous Systems • Invertebrates • Vertebrates • Posterior Pituitary Hormones • Oxytocin • Antideuretic hormone (ADH) • Anterior Pituitary Hormones • Each hypothalamic hormone is either a releasing or inhibiting hormone • Hormone Cascade Pathway • Tropic Hormones • Follicle-stimulating Hormone (FSH) • Luteinizing Hormone (LH) • Adrenocorticotropic hormone (ACTH) • Thyroid-stimulating hormone (TSH) • Nontropic Hormones • Prolactin (PRL) • Melanocyte-stimulating hormone (MSH) • Growth Hormones (GH) Hormone Cascade Pathway
Endocrine Glands • Thyroid Gland • Control of Metabolism and Development and Homeostasis • Thyroid Hormone: Triiodothyronine(T3) and thyroxine (T4) • Parathyroid Gland and Vitamin D • Control of Blood Calcium • Parathyroid Hormone (PTH)
Endocrine Glands Cont. • Adrenal Gland • Response to Stress • Adrenal Medulla • Catecholamines: Epinephrine and Norpinephrine • Adrenal Cortex • Corticosteroids: Glucocorticoids and Mineralocorticoids • Pineal Gland • Melatonin • Biorhythms • Gonads • Sex Hormones • Androgens • Testosterone • Estrogens • Estradiol • Progestins • Progesterone
Major Human Endocrine Glands and Some of Their Hormones Cont.
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