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Cellular Apoptosis Pathway

Growth Factor. Growth Factor. TNF a. Apo2L/ Apo3L. TNFR1. Caspase7. Procaspase8. Procaspase8. Procaspase8. Caspase8. FasL. Apo2/ Apo3. TRADD. TRADD. Fas. Growth Factor Receptor. RIP. PI3K. IKKs. TRAF2. tBID. p90RSK. Caspase3. BID. PKC. FADD. Akt1. NF- k B.

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Cellular Apoptosis Pathway

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  1. Growth Factor Growth Factor TNFa Apo2L/ Apo3L TNFR1 Caspase7 Procaspase8 Procaspase8 Procaspase8 Caspase8 FasL Apo2/ Apo3 TRADD TRADD Fas Growth Factor Receptor RIP PI3K IKKs TRAF2 tBID p90RSK Caspase3 BID PKC FADD Akt1 NF-kB NF-kB BIM BCL2 CIAP1 PMR VDAC ANT BAD SMAC BAX BAK FADD FADD FLIP Caspase9 IkBa p53AIP1 Arts ICAD CypD PUMA EndoG ZIPK HTRA2 Daxx AIF AIF BCLXL PAR4 CAD CAD PML Noxa Cytoc APAF1 EndoG 2009 ProteinLounge.com p14(ARF) MDM2 PARP ATM p53 p53 C Withdrawl of Growth Factors Cellular Apoptosis Pathway Apoptosis Mitochondria MMP Apoptosis Apoptosis Depolari- zation Oncogenic Signal POD DNA Fragmentation FLIP,CIAP2,BFL1, BCL2 BAK,BAK,BID, Ras,Noxa,PUMA, APAF1,Survivin, BCL2 DNA Fragmentation Apoptosis Chk2

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