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APOPTOSIS

APOPTOSIS. Apo: apart Ptosis: falling Shedding of leaves from trees!. Characteristics of Apoptosis. Shrinks. Blebbing. Nucleus breaks down, breaks into small membrane wrapped fragments. Importance of Apoptosis. Maturing organisms. Viruses. Immune System. DNA damage. What is a Caspase?.

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APOPTOSIS

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  1. APOPTOSIS Apo: apart Ptosis: falling Shedding of leaves from trees!

  2. Characteristics of Apoptosis • Shrinks. • Blebbing. • Nucleus breaks down, breaks into small membrane wrapped fragments.

  3. Importance of Apoptosis • Maturing organisms. • Viruses. • Immune System. • DNA damage.

  4. What is a Caspase? • Have been termed "executioner" proteins for their roles in the cell. • Plays an essential role in apoptosis, necrosis, and inflammation. • Two types of caspases; initiator (2,8,9,10) & effector caspases (3,6,7). • CASP 4,CASP 5 are not classified as initiator nor effector because they are inflammatory enzymes that, with the help of CASP 1,are involved in T-cell maturation.

  5. Apoptosis: Pathways Death Receptors Initiator Caspase 8 Effector Caspase 3 PCD Initiator Caspase 9 Mitochondria/Cytochrome C “Extrinsic Pathway” Death Ligands “Intrinsic Pathway” DNA damage & p53

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