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Descriptive vs. Quantitative Risk Assessment of Genotoxic Carcinogens

A workshop evaluating the benefits and disadvantages of using descriptive and quantitative methodologies in assessing the risk of genotoxic carcinogens.

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Descriptive vs. Quantitative Risk Assessment of Genotoxic Carcinogens

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  1. Welcome Descriptive vs. Quantitative Risk Assessment of Genotoxic Carcinogens 2nd April 2009

  2. Descriptive vs. Quantitative Risk Assessment of Genotoxic Carcinogens A workshop to evaluate the benefits and disadvantages of the application of descriptive and quantitative methodologies to the assessment of risk of genotoxic carcinogens

  3. IGHRC The Interdepartmental Group on Health Risks from Chemicals (IGHRC) is comprised of representatives from UK government departments, agencies and research councils with an interest in chemical risk assessment Full membership list available at: http://www.cranfield.ac.uk/health/ighrc

  4. IGHRC Activities IGHRC aims to reduce uncertainties and limitations in the conduct of chemical risk assessment through:   • development and publication of reports and guidance documents* as a means of promoting best practice, harmonisation and awareness of different risk assessment approaches among government departments and agencies • establishing specific issue working groups to develop and share expertise • the provision of training courses in the field of risk assessment *available from: http://www.cranfield.ac.uk/health/ighrc

  5. Workshop Agenda

  6. Weight of evidence approach For genotoxic carcinogens, it is not possible, in practice, to identify a threshold level below which no effect would be expected. Extrapolation from relatively high dose levels used in animal studies in order to estimate probable responses at lower doses in humans is very uncertain. Predictions also give an impression of precision that cannot be justified in the light of the approximations and assumptions on which they were based. The policy generally adopted in the UK for risk management of genotoxic carcinogens is based on eliminating exposures or reducing exposures so that they are as low as is reasonably practical. • Assessment of • chemical carcinogens: • Background to • general • principles • of a weight of • evidence approach cr 8

  7. Discussion Session • What are the current approaches adopted by UK government departments and agencies? • How does this compare to the risk assessment methodologies used across Europe/internationally? • What guidance has been produced? • Do the descriptive and quantitative approaches have particular use scenarios? • Does current guidance/opinion require further evaluation or summary?

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