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Cell Signaling

Cell Signaling. Communication between cells near and far… 1994 Nobel Prize in Physiology/Medicine. How could cell signalling relate to cancer???. Press Release. From the reading determine: What is a G protein? How does a G protein become activated? What can G proteins do in a cell?

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Cell Signaling

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  1. Cell Signaling Communication between cells near and far… 1994 Nobel Prize in Physiology/Medicine

  2. How could cell signalling relate to cancer???

  3. Press Release • From the reading determine: • What is a G protein? • How does a G protein become activated? • What can G proteins do in a cell? • How does the Cholera toxin affect G-protein signaling? • What is the role of a discriminator? An amplifier?

  4. Types of Signaling • Paracrine • Synaptic • Hormonal • Plants • Animals

  5. Overview of Cell Signalling • Campbell’s 11A • Ligand • Reception • Transduction • Response

  6. Types of Receptors • Campbell’s 11B • G protein • Tyrosine Kinase • Ligand Gated Ion Channels

  7. Signal Transduction Pathways • Campbell’s 11C • Second messenger • Protein Kinase

  8. Types of Cellular Response • Campbell’s 11D; G protein animation http://www.physioviva.com/movies/gpcr/index.html • Types of Cellular Responses: • Activation of a molecule. • Turning on/off protein • Gene activation • Opening/closing of ioin channels.

  9. Activity: G-protein signal transduction • You will be part of a g-protein signal pathway. • Identify yourself: Reception, Transduction, Cellular Response • What is your role?

  10. Experiment: Determining Environmental Conditions and Molecules used for signaling • Case Study for Chapter 11

  11. Human Growth Hormone Connection • Normal Activity • Altered Activity: Why would Roger Clemens take HgH? • Problems associated with taking HgH

  12. How is HgH different than testosterone? • Testosterone is a steroid • How is the signaling pathway different?

  13. Common Link: Destruction of Negative Feedback

  14. Followup--Bitter Taste Why do only some people taste bitter?

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