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Lab Animal Clinical Management

Lab Animal Clinical Management. Extra Credit. Please explain your position on biomedical research and the use of animals in this field the more effort you put into this, the more credit will be awarded

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Lab Animal Clinical Management

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  1. Lab Animal Clinical Management

  2. Extra Credit • Please explain your position on biomedical research and the use of animals in this field • the more effort you put into this, the more credit will be awarded • THERE IS ABSOLUTELY NO PENALTY FOR HAVING A SEPARATE OPINION than my own. Please Please explain how you feel and why. • written form is due Wednesday 3/5/14

  3. research - careful, patient, systematic, diligent inquiry or examination in a field of knowledge. undertaken to establish facts or principles • human life expectancy 1900 - 49 yrs • 2004 - 69.3

  4. Disease (USA) in millions • 61.8 cardiovascular • 50 hypertension • 24 hearing disorders • 20.5 cataracts • 17 diabetes • 0.7 leukemia • 0.7 lymphoma • 14 alcoholism • 40.5 arthritis • 4 Alzheimer’s • 2 schizophrenia • 0.4 MS • 0.007 SIDS

  5. Biomedical Research • area of science to investigate a biologic process or disease • comparative anatomy • this information is used to discover or advance any area of medicine (including medications, surgical procedures, treatments/therapy) • Prevent/Treat/Cure Disease in Animals and Humans

  6. 1940 - Polio • by 1960 BMR had developed a vaccine and nearly irradiated the disease • Antibiotics, Small Pox, Measles, Bone Marrow Transplants, Open-Heart Sx, pet meds/vax, human OTC, Rabies • to name only a few - current research is moving toward improved treatments and cures for cancer, Avian Flu, Ebola, AIDS • children outside of Third World Countries receive a polio vaccine in addition to typhus, diphtheria, whooping cough, smallpox, and tetanus • Diabetes

  7. 1978 - canine population was struck suddenly with worldwide outbreak of severe vomiting, diarrhea (dehydration) and frequent death

  8. Parvo (similar to feline panleukopenia) - canine vaccine tested, approved, and produced within 1 year • also FeLv, FIV

  9. table 1.1 pg 3biomedical breakthroughs

  10. husbandry • nutrition • behavior • health • reproduction • herd health • we must understand how to identify and treat stress and discomfort in the scope of the protocol

  11. biotechnological advancement • genetic-engineering • FDA • EPA • Consumer Product Safety Commission (CPSC) • OSHA • cruelty-free products - either indirectly tested or just plain untested- blindness, a med with a heinous side-effect

  12. Where • Universities • Hospitals • Pharmaceuticals • Farms • VTI

  13. AALAS Myth Slides5-12

  14. AALAS Jobs28-38

  15. Independent Study • Regulations - very straight forward, no room for interpretation. • You will be responsible for the following information come test time • Animal Welfare Act • Animal Welfare Information Center • GLP pg 18 • Public Health Service • The Guide • IACUC • AVMA • OLAW

  16. despite all my rage…

  17. Euthanasia

  18. 95% of studies end in euthanasia • AVMA Guideline for Humane Euthanasia • VTI

  19. The protocol dictates which animals will be euthanized and at what point. • This protocol is approved by the IACUC long before an animal is ever involved. • It also details how euthanasia is to take place and who is responsible for this procedure (depending on samples that may need to be taken following euthanasia)

  20. methods • CO2, Euthanex chamber • Injectable • YOU MUST BE TRAINED TO DO THIS

  21. Adoption • Sanctuary - Chimp Haven, Bastrop, • Retirement Sanctuary for Laboratory Animals

  22. Enrichment/Stress • absolutely paramount on the part of the animal care staff. • at minimum it affects research • the effects of stress must be controlled or the data is useless • parturition, breeding, serum chems, eating, enrichment, training, and the list goes on

  23. enrichment

  24. Animal Rights vsAnimal Welfare

  25. cruel - VTI? • dispassionate - proof? • PETA - importance? • animal rights vs animal welfare • Sarah McLachlan

  26. Replace • Reduce • Refine

  27. the stereotypical rights activists • does not believe in kenneling dogs • zoos/aquariums • food animals • abstain from Western medicine • broken hand, OTC meds, x-rays, sx, prosthetics • Sarah McLachlan - distortion of facts

  28. Kill vs Euthanize • Pets? • Welfare - the physical and psychological needs of the animals are paramount - the welfare of a biomedical research animal are directly proportional to the welfare of mankind

  29. there is a perspective that paints BMR as painful and torturous. the vast majority of procedures are non-painful for the animals and the other are treated appropriately by the veterinary team with analgesia and swift euthanasia PRN • these animals may experience disease in an effort to prevent or cure human disease

  30. PETA vs AMA - funding, public opinion • always remember the 3 Rs

  31. extremists • violent threats to doctors and staff at better-publicized institutions. labs are broken into, animals are stolen, equipment and data is destroyed • worst case scenarios have involved violence and bombings

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