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Intracoronary Serotonin and Endothelin Release After PCI

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Intracoronary Serotonin and Endothelin Release After PCI

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    2. Pharmacologic Agents Used to Treat Impaired Myocardial Perfusion*

    4. Pharmacologic Management of No Reflow: Nipride Nitroprusside (Nipride) Direct donor of nitric oxide 19 patients with no-reflow during native and SVG PCI 50-1,000 mg boluses of SNP (median 200 mg) Rapid improvement in TIMI flow (p<0.01) TFC (p<0.01)

    6. Impact of IC Adenosine on Flow and Echocardiographic Outcomes in the Setting Primary PTCA

    7. Impact of IC Adenosine on Clinical & Electrocardiographic Outcomes in the Setting Primary PTCA

    8. Lecture Notes The results of the angiographic substudy are shown here: Eptifibatide administration improved coronary flow reserve after adenosine compared to placebo from 1.28 to 1.78, p<0.02. Coronary flow reserve is the ratio of the velocity of blood flow after adenosine divided by the velocity of blood flow before adenosine. Higher ratios of coronary flow reserve indicate better health of the microvasculature. The rate of rise in the brightness of the myocardium after adenosine was nearly twice as great for patients receiving eptifibatide: 7.30 vs 3.97 gray per second, p=0.05. Likewise, the circumference of the blush tended to growth faster after adenosine. There was no excess in the myocardial staining or TIMI myocardial perfusion grade 1 among eptifibatide treated patients to account for the brighter digital subtraction results in patients treated with eptifibatide. References 1. Gibson CM, Murphy SA, Hynes C, Marble SJ, Cohen DJ, Cohen E, Lui HK, Kitt MM, Lorenz TJ, and Tcheng JE for the ESPRIT study group. Relationship of CK-MB Release to TIMI Myocardial Perfusion Grade Following Intracoronary Stent Placement: An ESPRIT Substudy. Am Heart J. 2002 Jan;143(1):106-110. Lecture Notes The results of the angiographic substudy are shown here: Eptifibatide administration improved coronary flow reserve after adenosine compared to placebo from 1.28 to 1.78, p<0.02. Coronary flow reserve is the ratio of the velocity of blood flow after adenosine divided by the velocity of blood flow before adenosine. Higher ratios of coronary flow reserve indicate better health of the microvasculature. The rate of rise in the brightness of the myocardium after adenosine was nearly twice as great for patients receiving eptifibatide: 7.30 vs 3.97 gray per second, p=0.05. Likewise, the circumference of the blush tended to growth faster after adenosine. There was no excess in the myocardial staining or TIMI myocardial perfusion grade 1 among eptifibatide treated patients to account for the brighter digital subtraction results in patients treated with eptifibatide. References 1. Gibson CM, Murphy SA, Hynes C, Marble SJ, Cohen DJ, Cohen E, Lui HK, Kitt MM, Lorenz TJ, and Tcheng JE for the ESPRIT study group. Relationship of CK-MB Release to TIMI Myocardial Perfusion Grade Following Intracoronary Stent Placement: An ESPRIT Substudy. Am Heart J. 2002 Jan;143(1):106-110.

    9. Integrilin in PCI and Filling of Muscle with Dye (Myocardial Blush)

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