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SYNERGY PCI A Subset analysis of the SYNERGY trial

SYNERGY PCI A Subset analysis of the SYNERGY trial. 4,687 high-risk ACS patients undergoing PCI after randomization to unfractionated heparin or enoxaparin. Enoxaparin 1mg/kg sc every 12 hours plus additional 0.3 mg/kg IV at time of PCI if procedure was more than 8 hrs after last sc dose.

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SYNERGY PCI A Subset analysis of the SYNERGY trial

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  1. SYNERGY PCIA Subset analysis of the SYNERGY trial 4,687 high-risk ACS patients undergoing PCI after randomization to unfractionated heparin or enoxaparin Enoxaparin 1mg/kg sc every 12 hours plus additional 0.3 mg/kg IV at time of PCI if procedure was more than 8 hrs after last sc dose Unfractionated heparin 60 U/kg bolus, then 12 U/kg per hour adjusted to an activated partial thromboplastin time of 50 to 70 seconds Primary Endpoint: Death/MI at 30 days

  2. SYNERGY PCI Death / MI by intent-to-treat analysis at 30 days Death MI Death or MI P=NS P=NS % P=NS

  3. SYNERGY PCI Bleeding in the intent-to-treat analysis at 30 days TIMI minor TIMI major GUSTO severe % P<0.05

  4. SYNERGY PCI • Among high-risk ACS patients undergoing PCI, the rate of death/MI at 30 days was not significantly different between patients treated with enoxaparin or unfractionated heparin. • Primary endpoint data for PCI patients is consistent with primary SYNERGY trial • As in primary SYNERGY trial, enoxaparin was associated with an increase in TIMI major bleeding

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