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This revision refines the classification of T cells into immature and mature subsets. It introduces "thymocyte" to replace immature T cells and enhances definitions for clarity. The concept of naïve versus antigen-experienced T cells is included, along with additional T helper subsets and transcription factors. Changes also involve collapsing immature and mature T cell terms, adding generic terms like helper T cell and memory T cell, and expanding the development stages in T cell overview.
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T cells • 34 terms for types of T cell currently exist in the Cell Ontology. • Broadly divided into immature and mature subsets, and into alpha-beta and gamma-delta subsets. • The genus term ‘T cell’ is the parent term for all types of T cell.
T Cell Ontology General issues for T cells • Introduce “thymocyte” to replace immature • Make definitions more precise. DN1 thymocyte - CD4- CD8- CD44+ CD25- • Introduce the concept of naïve versus antigen experienced T cell - instead of “mature” • Add additional T helper subsets - introduce transcription factors as part of the definition Changes made • Collapsed immature and mature T cell into the T cell term • Made definitions more precise. DN1 thymocyte - CD4- CD8- CD44+ CD25- • Added some generic terms such as helper T cell, memory T cell • A few cells have two parents • Expanded the development stages
