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Diabetes Management Charleston Academy January 2013

Diabetes Management Charleston Academy January 2013. Q.WHO ARE WE?. Q.WHY ARE WE HERE TODAY?. To talk to you about: applications of what you learn in class diabetes diabetes management through devices how these devices work. Q.WHO ARE . ?. Part of the Diabetes Care

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Diabetes Management Charleston Academy January 2013

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  1. Diabetes Management Charleston Academy January 2013

  2. Q.WHO ARE WE?

  3. Q.WHY ARE WE HERE TODAY? • To talk to you about: • applications of what you learn in class • diabetes • diabetes management through devices • how these devices work

  4. Q.WHO ARE ? Part of the Diabetes Care Franchise of

  5. WHAT DO DO? We make: ‘self monitoring blood glucose’ (SMBG) measurement systems to help people with diabetes control their blood sugar concentration

  6. SMBG systems

  7. Q. WHAT IS DIABETES? • Chronic condition (long term) • Caused by failure of pancreas to produce sufficient insulin and/or • Failure of the body to use insulin produced effectively (insulin resistance) • Body cannot use energy from food • Leads to uncontrolled blood sugars

  8. Q: WHAT ARE THE TYPES OF DIABETES? • Type 1 diabetes • Type 2 diabetes • Gestational diabetes (during pregnancy) • Secondary diabetes • Pre diabetes states • Impaired Glucose Tolerance • Impaired Fasting Glycaemia

  9. DIABETES OVERVIEW Population  9% of Diabetes population Onset usually by puberty Death results without insulin Represents 35% of strip utilization Type 1  2 M Type 2  91% of Diabetes population Adult Onset – Average age of diagnosis is 56 Body Resistant to Insulin Risk Factors include lifestyle, obesity, genetics Represents 65% of strip utilization  18 M . Diagnosed Diabetics In the Unites States Source: ADA, LifeScan Internal Data

  10. Prevalence of Diabetes worldwide In million people 33 15 19 36 47 7 14 1 About 50% of diabetics go undiagnosed

  11. Worldwide Diabetes Epidemic 366MM 200MM Diabetes population nearly doubles by 2030 Source: World Health Organization

  12. Q. WHAT is the most important sugar to control? Glucose = blood sugar Gets pumped round in the blood (along with oxygen) Reaches the cells where it reacts to release energy! Glucose + Oxygen  Carbon dioxide, water + ENERGY

  13. Q. What do the terms Hypoglycaemia and Hyperglycaemia mean? Non diabetic glucose concentration range: 4:8mmol/L* ~0 :30+mmol/L* Uncontrolled diabetic concentration range: Note: The symptoms of Hypo and Hyper glycaemia are very similar! *1mmol = 1/1000th of 1 mole , 1L = 1dm3 , 1mmol/L = 0.001 mol/dm3

  14. Q.WHY DO WE MAKE SMBG SYSTEMS? If people with diabetes do not control their blood Sugar concentration there can be complications in the short and long term.

  15. An important question... Is anyone squeamish??? In that case...

  16. Long Term Complications

  17. Q. SO HOW DO OUR SMBG SYSTEMS WORK? …BIOCHEMISTRY! Chemistry is in the test strip

  18. In Summary Complicated system controls blood sugars: But if something goes wrong with this? insulin food How Much Insulin? When? Your SMBG System will help you keep control!

  19. Q. WHAT IS AN ENZYME? - Enzymes are Biological Catalysts! SPEED UP CHEMICAL REACTIONS! Don’t need much! React again and again without being consumed (££££) • Enzymes are very specific to • a substrate! “Bio-recognition” useful for analysis within complex mixtures e.g. whole blood!

  20. Meet one of our enzymes: Glucose Oxidase - Mol weight = 160,000!!! (glucose is 180) - Purified from a Fungus! - An expensive yellow powder! Each test strip has about 5 millionths of 1 gram of Glucose Oxidase on it!

  21. Now for the fun bit…the Practical Enzyme chemistry - How does the chemistry work? - Does maltose react with the enzyme? - Does glucose react with the enzyme? - What happens when you add more or less glucose/enzyme? - What is the mystery sugar? Make your own SMBG test strip - Learn how the strips are made - Describe the different layers of the strip - Complete the strips by adding the chemistry and tapes - See if you can get a meter reading from your test strips

  22. Thanks for listening… Now you have a go!

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