microangiopathic hemolytic anemia

1. microangiopathic hemolytic anemia

2. microangiopathic hemolytic anemia

3. TTP

4. reticulocytes

5. Polychromasia

6. Autoimmune hemolytic anemia

7. Target Cells • Increased surface to volume ratio • Actually shaped like a bell (3D) • Target cells are always hypochromic • Excess membrane cholesterol and phospholipid • Decreased osmotic fragility

8. Target Cells • Hemoglobin C disease • Liver disease • Iron deficiency • Any hemoglobin abnormality • Post splenectomy

9. Target Cells (Codocytes)

10. Target Cells

11. 10 y/o boy of Italian descent Diagnosis : Beta thalassemia major Homozygous beta0 thalassemia Comment : beta0 = beta gene producing no beta chains no beta chains and hence no Hb A. untreated he has about 95% Hb F (remainder being Hb A2) Treatment : Transfusion to maintain hemoglobin level; Chelation therapy to remove excess iron present due to hemolysis and transfusions. Bone marrow transplantation is treatment of choice

12. Case 2 Sickle cell Howell Jolly Body Erythroblast

13. Sickle cells (Drepanocytes)

14. Sickle Cells

16. Sickle Cells