1 / 18

Patent Ductus and Vascular Occlusion Devices

Patent Ductus and Vascular Occlusion Devices. Michelle Carlsen Elaine Isom Brad Klosterman Ornob Roy Advisor: Dr. Thomas Doyle. Project Definition. Objective : Design, build, and market an occlusion device which can be used for Patent Ductus and cylindrical vasculature

rasia
Download Presentation

Patent Ductus and Vascular Occlusion Devices

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Patent Ductus and Vascular Occlusion Devices Michelle Carlsen Elaine Isom Brad Klosterman Ornob Roy Advisor: Dr. Thomas Doyle

  2. Project Definition • Objective: Design, build, and market an occlusion device which can be used for Patent Ductus and cylindrical vasculature • Presentation topics: • Background • solution • accomplishments • current status • future plans

  3. Background:Patent Ductus • Infants/Children • ~ 10-12% of congenital defects • 40 cases/yr at Vanderbilt • > 20,000 nationwide • Connection btw pulmonary artery and aorta

  4. Background:General Vasculature • Less common than PDA • Cylindrical shape • Reroute blood flow • Isolate defective vasculature • Impede significant flow

  5. Diagnosis: Heart murmur Extreme weight loss Stunted growth Irregular blood flow* * General vasculature Consequences: Irreversible pulmonary-vascular disease Congestive heart failure Hemorrhaging (e.g. diabetics, post-surgical patients)* PDA/ Vascular Conditions

  6. Requirements • Biocompatible • Quick endothelialization (1-2months) • Delivered through a catheter < 2mm diameter • Simple, Retrievable • Inexpensive • Various size (2 to 10mm) • Form-fitting • Maximum effectiveness

  7. Endomethiasin steroid medicine (vasoconstrictor) restricted to premature infants Suturing effective invasive, long recovery Coils inexpensive not form fitting Titanium devices form fitting very expensive Ultrasonic Devices non-invasive high-intensity not human tested Solutions

  8. Accomplishments • Identification of associated diseases • Analysis of previous device designs • Studies in biocompatible materials (Prof. Kinser, Material Sciences) • Fluoroscopy viewing • SDRC I-DEAS CAD/CAM modeling

  9. I-DEAS Modeling

  10. Current Status • 3D modeling using SDRC I-DEAS • Material search • 3 design concepts • Large scale simulation: drawings, materials

  11. Design 1 • Advantages: • adjust on contact • expandable polymer • form-fitting (PDA & general) • Disadvantages: • FDA • expensive (polymer & wire • retrievable??

  12. Design 2 • Advantages: • form-fitting (PDA & general) • collapsible (>500%) • endothelialize quickly • inexpensive • Disadvantages: • complex • possible limited retrieval

  13. Design 3 • Advantages: • form-fitting (PDA & general) • retrievable • simple • inexpensive • Disadvantages: • expansion limitations?? • Two materials

  14. Material Search • Zotefoams • plastazote foam (polyethylene) • Medicell • medical sponges • Titanium/wire material • Thrombosing fibers • Polyurethane foam (earplugs) • Polyurethane that is modified with lower alkyl Sulfonate and L(L-glutamic acid co L-leucine) • biocompatible, used in surgical implantations and blood contacting procedures

  15. Elaine/Michelle: PDA design material search literature analysis/search Ornob/Brad: Vascular Occluder Design modeling using I-DEAS simulation design idea Group: device design ideas large scale prototypes designsafe analysis Division of Labor

  16. Future Plans • Decide on final design • Acquire materials for design • Continue meeting with Dr. Doyle • Designsafe analysis • Large scale replication • Patent

  17. Simulation Echigo, S et al. “ Development of New Transvenous Patent Ductus Arteriosis Occlusion Technique Using a Shape Memory Polymer.” ASAIO Transactions: 1990 pg M197.

More Related