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What do we know about addictive drugs from animal studies?

This article explores the effects of addictive drugs such as cocaine, morphine, nicotine, and ethanol on dopamine transmission in the BNST. It suggests that dopamine transmission in the BNST plays a role in drug abuse and addiction mechanisms.

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What do we know about addictive drugs from animal studies?

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  1. What do we know about addictive drugs from animal studies? “… cocaine, morphine, nicotine, and ethanol share the property of increasing DA transmission in the BNST. This effect may be related to an action at the level of neuronal circuits activated by natural reinforcers … suggest[ing] that DA transmission of the BNST plays a role in the mechanism of drug abuse and addiction.” Carboni, … DiChiara et al. J Neurosci 20:RC102(1-5), 2000

  2. aaarrrggghhhh!!!!! – show me DBP

  3. what phenomenon is this?

  4. does everyone understand what they are showing here? plot R value at given voxel euphoria Individual subjects (need to have all brains in same space) DBP

  5. -12 -2 40 50 de-nic cig nic cig

  6. mu D2

  7. No CS unexpected reward from: Schultz, Dayan, & Montague, 1997, Science. CS predicted reward CS absence of predicted reward

  8. mu

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