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PXR mediated metabolism of Vitamin D. DPH CBZ PB. PXR. VDR. +. Cholesterol. +. CYP 24. 25 (OH) 2 D 3. Calcitroic Acid (Inactive). 1 α ,25 (OH) 2 D 3. ↓ Ca ↑ PTH. Low Active Vitamin D.
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PXR mediated metabolism of Vitamin D DPH CBZ PB PXR VDR + Cholesterol + CYP 24 25 (OH)2 D3 Calcitroic Acid (Inactive) 1α,25 (OH)2 D3 ↓Ca ↑ PTH Low Active Vitamin D