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Ebola River Hemorrhagic Fever

Ebola River Hemorrhagic Fever. Glamour disease of the1990s. Ebola Hemorrhagic Fever Virus. Filoviridae , cell wall & RNA. Ebola electron-micrograph in human skin tissue & evolutionary relationships of Ebola & Marburg viruses. Family Filoviridae. Extreme biological hazards.

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Ebola River Hemorrhagic Fever

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  1. Ebola River Hemorrhagic Fever

  2. Glamour disease of the1990s

  3. Ebola Hemorrhagic Fever Virus Filoviridae, cell wall & RNA

  4. Ebola electron-micrographin human skin tissue & evolutionary relationships of Ebola & Marburg viruses Family Filoviridae

  5. Extreme biological hazards

  6. Ebola Outbreak History 2005 Angola Marburg 257 235 92%

  7. Liver tissue, 1:38 after Ebola infection Ebola infected cell

  8. Liver tissue, 8:47 > Ebola infection

  9. Ebola Case Fatalities 60-80%

  10. Ebola outbreak locations

  11. Possible Ebola Transmission(s)no usual suspects! It is unknown where the virus dwells…

  12. Community Epidemic Scenario • Secondary transmission within species. • Reciprocal transmission between species. APES/HUMANS INTERMEDIATE HOST RESERVOIR Peter Walsh et al. Nature (2003) Just because a species tests positive for virus or antibodies does not mean that it is a link in the chain of transmission to apes. “Cul de Sac” Hosts Cul de Sac HOST--HUMANS? APES RESERVOIR

  13. All Ebola Hemorrhagic Fever Outbreaks have occurred in African Tropical Forests

  14. Some Ebola outbreaks have occurred in African gallery tropical forest within a savanna matrix

  15. NOAA 14 AVHRR MODISes NOAA 11 AVHRR NOAA 9 AVHRR SPOT NOAA 7 AVHRR 1980 1985 1990 1995 2000 2005 2010 SeaWiFS Global NDVI data sources 1981 ---> 2011… NOAA-16 NPP NOAA-17 NOAA9

  16. Hypothesis: very extreme antecedent dry season followed by strong rainy season

  17. the hottest zone ?? These outbreaks don’t conform--travel caused?

  18. Trigger event summary 1991? Threshold?

  19. Ebola River Hemorrhagic Fever ???

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