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ALD and Muscular Dystrophy

ALD and Muscular Dystrophy. Heather Vandevanter Period 2. ALD Adrenoleukodystrophy. OVERVIEW Myelin (insulation around nerves) breaks down over time Nerves can’t function properly or at all w/out Myelin Progressive disorder. WHAT CAUSES ALD? WHO GETS IT?

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ALD and Muscular Dystrophy

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  1. ALD and Muscular Dystrophy Heather Vandevanter Period 2

  2. ALDAdrenoleukodystrophy OVERVIEW • Myelin (insulation around nerves) breaks down over time • Nerves can’t function properly or at all w/out Myelin • Progressive disorder

  3. WHAT CAUSES ALD? WHO GETS IT? • Body can’t break down fat molecules which build, clog, and hurt nerve cells in brain/spinal cord • Inherited Genetic disorder linked to X (woman) chromosome

  4. DO ALL ALD PATIENTS DIE? • 45% of cases devastating (nerves in brain are destroyed w/in 6 mo. to 2 yrs.) • 45% of cases = AMN (adrenomyeloneuropathy). Like Multiple sclerosis, there’s body damage, not brain • 10% of ALD cases start with Addison’s disease and may slowly move to AMN (least severe)

  5. CAN ALD BE CURED? • Olive oil / Low fat diet? • Lovastatin drug? • Bone Marrow Transplant? • Hormone replacement?

  6. MUSCULAR DYSTROPHY OVERVIEW • Progressive weakness / degeneration of skeletal muscles that control movement • Birth- Congenital Muscular Dystrophy • Adolescence- Becker Muscular Dystrophy

  7. IS MUSCLE DYSTROPHY ALWAYS DEVASTATING? • Three Types: • Duchenne: Mutation in gene that regulates Dystrophin, or protein the maintains muscle fiber ( walk- 12, breath- 20) • Facioscapulohumeral: Progresses slowly (mild  disabling) • Myotonic: Characterized by Myotonia (prolonged muscle spasms) • Can be treated w/ certain meds

  8. CAN MUSCULAR DYSTROPHY BE CURED? • Like ALD, still no cure • Respitory/Physical Therapy for Muscles • Orthopedic appliances for support

  9. THE END

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