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Oe sophageal C ancer

Oe sophageal C ancer. Katja Prašek- Kudrna Mentor: A. Žmegač Horvat. Types. Benign (10%) Epithelial Mesenchymal Malignant (90%) Epithelial Mesenchymal Others. Epidemiology. In the top 10 malignant tumors Geographic variability 4 times more frequent in ♂ Elderly. Etiology.

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Oe sophageal C ancer

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  1. OesophagealCancer Katja Prašek- Kudrna Mentor: A. Žmegač Horvat

  2. Types • Benign (10%) • Epithelial • Mesenchymal • Malignant (90%) • Epithelial • Mesenchymal • Others

  3. Epidemiology • In the top 10 malignant tumors • Geographic variability • 4 times more frequent in ♂ • Elderly

  4. Etiology • Alcohol and smoking • Other carcinogens • Damage of the oesophagus • Deficiency of Mb, Zn and vitamin A • GERD • HPV • Other illnesses

  5. Pathology • Microscopic • Squamous cell cancer • Adenocarcinoma • Macrosopic • Superficial form • Polyp • Ulcer • Infiltrative form

  6. Signs and symptoms • 90% - dysphagia and weight loss • Aspiration pneumonia and cough • Hoarseness • Horner syndrome • Palpableneck lymph nodes • Hypercalcaemia • Bleeding • Infection

  7. Diagnostics • X rays • Oesophagoscopy (histology and cytology) • Endoscopic ultrasound • CT and PET • Bronchoscopy

  8. Prognosis and Treatments • Radiochemotherapy • SURGICAL- total/ partial oesophagostomy • CYTOSTATICS- cisplatin, 5- fluorouracil • PALLIATIVE TREATMENT- stent or laser rechanneling • 5 year survival < 5%

  9. References • Vrhovac, Jakšić, Reiner, Vucelić: Interna medicina, naklada Ljevak, Zagreb 2008 • Robbins: Basic Pathology, Saunders Elsavier, 2007 • http://en.wikipedia.org/wiki/Esophageal_cancer

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