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Maurice Wilkins… and…

1953 | 1962. Maurice Wilkins… and…. Rosalind Franklin (1920-1958). Interesting note…. Ratio of A-T::G-C affects stability of DNA molecule 2 H bonds vs. 3 H bonds biotech procedures more G-C = need higher T° to separate strands high T° organisms many G-C parasites

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Maurice Wilkins… and…

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  1. 1953 | 1962 Maurice Wilkins… and…

  2. Rosalind Franklin (1920-1958)

  3. Interesting note… • Ratio of A-T::G-C affects stability of DNA molecule • 2 H bonds vs. 3 H bonds • biotech procedures • more G-C = need higher T° to separate strands • high T° organisms • many G-C • parasites • many A-T (don’t know why)

  4. Another interesting note… • ATPAdenosine triphosphate • modified nucleotide • adenine (AMP) + Pi + Pi + +

  5. HELIXHELIX

  6. Macromolecule Review

  7. Carbohydrates • Structure / monomer • monosaccharide • Function • energy • raw materials • energy storage • structural compounds • Examples • glucose, starch, cellulose, glycogen glycosidic bond

  8. Lipids • Structure / building block • glycerol, fatty acid, cholesterol, H-C chains • Function • energy storage • membranes • hormones • Examples • fat, phospholipids, steroids ester bond (in a fat)

  9. Proteins • Structure / monomer • amino acids • levels of structure • Function • enzymes u defense • transport u structure • signals u receptors • Examples • digestive enzymes, membrane channels, insulin hormone, actin peptide bond

  10. Nucleic acids • Structure / monomer • nucleotide • Function • information storage & transfer • Examples • DNA, RNA phosphodiester bond

  11. Building the polymer

  12. RNA & DNA • RNA • single nucleotide chain • DNA • double nucleotide chain • N bases bond in pairs across chains • spiraled in a double helix • double helix 1st proposed as structure of DNA in 1953 by James Watson & Francis Crick(just celebrated 50th anniversary in 2003!)

  13. Information polymer • Function • series of bases encodes information • like the letters of a book • stored information is passed from parent to offspring • need to copy accurately • stored information = genes • genetic information Passing on information?Why is this important?

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