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Setting the Stage – PAH Therapy Trials

Setting the Stage – PAH Therapy Trials. Current PAH Pharmacotherapies. History of LHF Therapy. Disease Modification in LHF. HFrEF Lessons Learned – Moving Forward in PAH. RV Structure and Function in PH – The Downward Spiral. Growth and Immune Response Dysregulation in PAH.

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Setting the Stage – PAH Therapy Trials

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  1. Setting the Stage – PAH Therapy Trials

  2. Current PAH Pharmacotherapies

  3. History of LHF Therapy

  4. Disease Modification in LHF

  5. HFrEF Lessons Learned – Moving Forward in PAH

  6. RV Structure and Function in PH – The Downward Spiral

  7. Growth and Immune Response Dysregulation in PAH

  8. RV Function in PAH

  9. Lessons From HFpEFRV-PA and RV-LV Interactions

  10. Right Heart and Survival in PAH – REVEAL Registry Data

  11. RV-PA and RV-LV Interactions

  12. Evolution of End Point-Driven Trials in PAH

  13. Current and Future Challenges in End Point Design

  14. Right Heart vs Left Heart Therapies

  15. Designing PAH Trials – The Next Steps

  16. Combination Therapy in PAH

  17. Combination Therapy in PAH (cont)

  18. Conclusion

  19. Abbreviations

  20. Abbreviations (cont)

  21. References

  22. References (cont)

  23. References (cont)

  24. References (cont)

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