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Biosensor using aptamer

Biosensor using aptamer. C ontents. What is biosensor? What is aptamer ? How can we use aptamer ? How can we find aptamer ?. What is Biosensor?. Analytical device using biological element Sensing organic molecule’s state or concentration. Biomarker of Heart attacks.

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Biosensor using aptamer

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  1. Biosensor using aptamer

  2. Contents • What is biosensor? • What is aptamer? • How can we use aptamer? • How can we find aptamer?

  3. What is Biosensor? • Analytical device using biological element • Sensing organic molecule’s state or concentration

  4. Biomarker of Heart attacks

  5. What is aptamer? • Piece of single strand DNA or RNA • High affinity for certain molecule • Used for bioreceptor of biosensor

  6. Small size  easy production, modification • High stability  easy to handle, regeneration • Economically efficient • No immune rejection response • Adjust to many toxic material or complex protein

  7. How can we find aptamer? vitro selection SELEX(Systematic Evolution of Ligands by Exponential Enrichment)

  8. Different kind of SELEX • Cell SELEX • Capillary electrophoresis SELEX (CE SELEX) • Speigelmer

  9. How can we use aptamer? • Sensor • Diagnosis • Cure

  10. Discussion • Where can aptamer be used in another way?

  11. Reference • 장승훈, 정기준, 압타머(Aptamer) 개발의 최근 연구 동향, 한국과학기술원 생명화학공학과 • Li Cai, Ze-Zhong Chen, Min-Yan Chen, Hong-Wu Tang*, Dai-Wen Pang, MUC-1 aptamer-conjugated dye-doped silica nanoparticles for MCF-7 cells detection, 2013, Biomaterials

  12. Thank you!!

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