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B cells. Humoral immune response. Antigen receptors on lymphocytes. B cell. T cell. Antigens : protein s , polysaccharides , lipid s , nucleic acids, small molecules Conformational and linear epitops. Complex of peptid e -MHC molecule on an AP C Linear epitop s. B cell maturation.
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B cells Humoral immune response
Antigen receptors on lymphocytes B cell T cell Antigens: proteins, polysaccharides, lipids, nucleic acids, small molecules Conformational and linear epitops Complex of peptide-MHC moleculeon an APC Linear epitops
pre B receptor pre B pro B
Active Btk enables: survival, proliferation and further maturation etc. Mutation of BTK gene: X-linked agammaglobulinemia (Bruton’s agammaglobulinemia) Btk (Bruton’s tyrosine kinase)
IgM pre B receptor immature B pre B pro B
IgM pre B receptor pre B IgD IgM mature B immature B pro B
IgD IgM MHC II CD40 B-7
Humoral immune response Thymus-independent (T-independent, TI) Thymus-dependent (T-dependent, TD)
Activation of B cells (two-signal requirement)
Activation of B cells (intracellular signaling)