1 / 23

B cells

B cells. Humoral immune response. Antigen receptors on lymphocytes. B cell. T cell. Antigens : protein s , polysaccharides , lipid s , nucleic acids, small molecules Conformational and linear epitops. Complex of peptid e -MHC molecule on an AP C Linear epitop s. B cell maturation.

savannah-gomez
Download Presentation

B cells

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. B cells Humoral immune response

  2. Antigen receptors on lymphocytes B cell T cell Antigens: proteins, polysaccharides, lipids, nucleic acids, small molecules Conformational and linear epitops Complex of peptide-MHC moleculeon an APC Linear epitops

  3. B cell maturation

  4. B cell maturation

  5. pro B

  6. pre B receptor pre B pro B

  7. Active Btk enables: survival, proliferation and further maturation etc. Mutation of BTK gene: X-linked agammaglobulinemia (Bruton’s agammaglobulinemia) Btk (Bruton’s tyrosine kinase)

  8. IgM pre B receptor immature B pre B pro B

  9. IgM pre B receptor pre B IgD IgM mature B immature B pro B

  10. IgD IgM MHC II CD40 B-7

  11. Humoral immune response Thymus-independent (T-independent, TI) Thymus-dependent (T-dependent, TD)

  12. Subsets of B cells

  13. Phases of humoral immuneresponse

  14. Activation of B cells (two-signal requirement)

  15. Activation of B cells (intracellular signaling)

  16. Functional consequencesof B cell activation

  17. Functional consequencesof B cell activation

  18. Functions of antibody isotypes

  19. Primary and secondary antibody response

More Related