Earl W. Sutherland, Jr Discovery of Cyclic AMP

1. Heritage of the CWRU Department of Pharmacology Earl W. Sutherland, Jr Discovery of Cyclic AMP FeridMurad Nitric Oxide Signaling Nobel Prize Alfred G. Gilman G-protein Signal Transduction

2. Continuing Tradition of Excellence in Pharmacology at CWRU • First high resolution structure of a G-protein coupled receptor (GPCR) • most common target of modern drug development In the top five of most highly cited articles in Biology / Biochemistry Thomas Reuters Survey Kris Palczewski, Chairman of Pharmacology

3. Molecular Therapeutics Training Program ( MTTP ) Translational Therapeutics Membrane Structural Biology & Pharmacology The NIH-funded Molecular Therapeutics Training Program (MTTP) involves faculty from six major research centers in Cleveland - CWRU, University Hospitals, Case Comprehensive Cancer Center, Cleveland Clinic Foundation, Cleveland VA Medical Center, and MetroHealth Medical Center. Students enter the Pharmacology Graduate Program directly, or via the Biomedical Sciences Training Program (BSTP) or the Medical Sciences Training Program (MSTP). Pharmacology Core Course Cellular / Molecular Biology & Research Rotations Prelim Exams Molecular Pharmacology & Cell Regulation Cancer Therapeutics Core and Advanced Tracks • The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics, preparing them for independent careers in research and teaching in a variety of academic or industrial settings.

4. Molecular Therapeutics Training Program ( MTTP ) Translational Therapeutics Membrane Structural Biology & Pharmacology The Molecular Pharmacology and Cellular RegulationTrackpromotes common research interests in molecular mechanisms of drug actions and regulatory processes that are potential targets for drug development. Pharmacology Core Course Cellular / Molecular Biology & Research Rotations Prelim Exams Molecular Pharmacology & Cell Regulation Cancer Therapeutics Core and Advanced Tracks • The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics, preparing them for independent careers in research and teaching in a variety of academic or industrial settings.

5. Molecular Pharmacology and Cellular Regulation Track Andrea Boyd-Tressler and George Dubyak • Novel role of ATP as a chemoattractant that facilitates • the immune component of the anti-tumor response • associated with cancer chemotherapy … Luke Bury and Shasta Sabo • Modern electrophysiology and imaging used to discover the mechanisms by which nerve synapses are formed in the developing brain - discovering the basis for autism … Meghana Gupta and Danny Manor • Learning how phosphorylation of tyrosine residues affects the biochemical and physiological activities of proteins that regulate G-protein signaling – discovering anti-cancer targets …

6. Molecular Therapeutics Training Program ( MTTP ) Translational Therapeutics Membrane Structural Biology & Pharmacology Pharmacology Core Course Benefiting from the Case Comprehensive Cancer Center, the Cancer Therapeutics Track fosters common interest in the concepts of cancer biology that form the basis for specific therapeutic strategies. Cellular / Molecular Biology & Research Rotations Prelim Exams Molecular Pharmacology & Cell Regulation Cancer Therapeutics Core and Advanced Tracks • The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics, preparing them for independent careers in research and teaching in a variety of academic or industrial settings.

7. CancerTherapeuticsTrack Chris Ryder Clark Distelhorst • Studies of mechanisms of regulation of lymphocyte apoptosis via the TDAG8 G protein-coupled receptor in the context of leukemia.… MollyTaylorBilllSchiemann • “The role of the microenvironment in mediating breast cancer progression.  Specifically I'm interested in the role of microRNAs on TGF-beta mediated-metastatic progression…”

8. Molecular Therapeutics Training Program ( MTTP ) Translational Therapeutics Membrane Structural Biology & Pharmacology Pharmacology Core Course The Translational Therapeutics Track interfaces basic science trainees with physician-scientists around a common interest in developing / improving the use of therapeutic agents in a rational and individualized manner. Cellular / Molecular Biology & Research Rotations Prelim Exams Molecular Pharmacology & Cell Regulation Cancer Therapeutics Core and Advanced Tracks • The MTTP provides students with outstanding training in the cellular, molecular, and physiological basis for therapeutics, preparing them for independent careers in research and teaching in a variety of academic or industrial settings.

9. Translational Therapeutics Track Michele Mumaw Marvin Nieman • Antiplatelet therapeutics…”my project examines an agent that has ideal characteristics; it delays thrombosis but does not influence bleeding time…” Peter Levitt Robert Bonomo • Structure function studies of Class A beta-lactamases. Understanding the factors that permit the successful evolution of beta-lactamases in the clinic… Amar Desai Stan Gerson • “I study the role of DNA repair in hematopoietic stem cells to understand the relationship between DNA repair, cell cycle status, and hematopoietic stem cell function.…”

11. Structural Biology & Pharmacology Track … Understanding the function of telomerase in DNA replication pertaining to aging and cancer chemotherapy Mike Mullins Derek Taylor Studying the molecular dynamics of Drp 1 in mediating mitochondrial fission & fusion pertinent to neurodegenerative diseases Jason Mears Chris Francy Determining the structure of isolated discs from the rod cells of the eyes of mouse models of human eye diseases Phoebe Stewart Director, CCMSB NeetuGulati

12. Electron Microscopy NMR X-ray generator Crystal robot Mass spec, computational modeling, one of the 3 largest, best equipped facilities in the world!