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Question 1:

Question 1: You have joined a lab for your graduate studies and your project is to study a mutation in MCL1 that was discovered in an Argentinian family with a history of cancer.

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Question 1:

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  1. Question 1: • You have joined a lab for your graduate studies and your project is to study a mutation in MCL1 that was discovered in an Argentinian family with a history of cancer. • This mutation is K123A. From patient biopsies, your initial observation is that MCL1 is localized to mitochondria in tumor cells and nucleus in the normal cells of a cancer patient. • Why might this observation be significant? Describe several experiments you could undertake to understand the biology of K123A mutation. • Question 2: • You have finished your PhD and you have just started your post-doc training. Your project is to investigate a novel protein ZYX with the following characteristics and observations: • 1. ZYX binds to the kinase mTOR • 2. ZYX has 89% similarity to the E3 ligase bTrCP. • 3. ZYX is deleted in 3% of human cancers • 4. ZYX has a PKB/AKT consensus phosphorylation site as follows: WRMRAGTVP. • Describe various experiments to explore the biology of your novel protein ZYX.

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