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MHRD Fast Program

CoE in Tissue Engineering Presented by. MHRD Fast Program. National Institute of Technology, Rourkela. Objective of the Center. Development of Infrastructure /Research Facility of International Standard. Development of research facility of International Standard. Teaching & Training.

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MHRD Fast Program

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  1. CoE in Tissue Engineering Presented by MHRD Fast Program National Institute of Technology, Rourkela

  2. Objective of the Center Development of Infrastructure /Research Facility of International Standard Development of research facility of International Standard Teaching & Training Development of research facility of International Standard Research & Development • Societal development Development of research facility of International Standard

  3. Research Objectives… Development of novel Scaffolds for tissue engineering application Biomechanics Cryo preservation of hMSCs, derived from Different sources & constructs & Grafts Cryo preservation of tissue engineered Bone, cartilage muscle & Skin Grafts Tissue Engineering Group & Its research Bone, Cartilage, Skeletal muscle Tissue Engineering Genetic reprogramming of cells for tissue engineering application Bimicrofluidics based microreactor for cell culture. Lab-on-Chip system for tissue engineering application Development of smart material Surface modification of biomaterials

  4. Progress in during April-Sept, 2006

  5. Focus areas of research • Development of engineered bone scaffolds & Bone tissue graft • Development of engineered Cartilage scaffold & cartilage tissue graft • Development of engineered musculo skeletal scaffolds & Muscle tissue graft • Production of Stem Cell • Development of Cryopreservation technology for stem celss and tissue grafts

  6. Publication(April-Sept 2016) • B.N. Singh, N.N. Panda, R. Mund, K. Pramanik (2016) Carboxymethyl cellulose enables silk fibroin nanofibrous scaffold with enhanced biomimetic potential for bone tissue engineering application, Carbohydrate Polymer, 151, 335-347. (Elsevier, IF: 4.689) • Serum-free non-toxic freezing solution for cryopreservation of human adipose tissue-derived mesenchymal stem cells, S S Ray, K. Pramanik, S. K. Sarangi, N Jain (2016) Biotechnology Letter, 38, 1397-404. (Springer, IF:1.639) • K. Pal, S. S. Sagiri, V. K. Singh, B. Behera, I. Banerjee, K. Pramanik (2016) “Natural Polymers in Tissue Engineering: Methods of scaffold fabrication and Applications” in “Encyclopedia of Biomedical Polymers and Polymeric Biomaterials”, Taylor & Francis Group, USA, p-5619-5649. • T. Kaur, A. Thirugnanam and K. Pramanik, Carbon nanomaterials reinforced poly(lactic-co-glycolic acid) composites for bone tissue engineering, World Biomaterials Congress May 2016, Montreal, Canada • M. Sivasankari, K. Pramanik, Silk based tissue engineering construct using rapid prototyping technique. International conference on Biomaterial, Biodignostics, Tissue Engg. Drug Delivery and Regenerative Medicine April 15-17 2016 at IIT Delhi, India. • B.N. Singh, K. Pramanik, A Novel Approach To Fabricate Aqueous Silk Fibroin Based Nanofibrous Mats With Enhanced Mechanical Properties, International conference  on Biomaterial, Biodignostics, Tissue Engineering, Drug Delivery and Regenerative Medicine April 15-17 2016 at IIT Delhi, India.

  7. Notable achievements: Patents/Products/Prototypes developed so far

  8. A snap of technology/product/device development Chitosan/β-TCP composite scaffolds & SEM image

  9. Snap shots contd… Bone construct Cartilage Constructs Constructs generation in bioreactor

  10. Snap shots contd… Cell – Seeded Scaffold

  11. Snap Shot cont.--- In house built 3D printing machine & fabricated scaffold Small Scale Stem Cell Banking Facility

  12. Interaction with industry, relevance to Indian Technology needs, Economic Advancements resulting as a consequence

  13. Adoption of Villages Project Area : Rural Village (s) : Santospur Block/Taluka : Bishra District : Sundargarh State : Odisha • Healthcare awareness program: General health care issues like sanitation, food & nutrition, common infection & prevention • Motivating & capacity building by launching micro-enterprises in the area of cultivation of medicinal plant & preparation of plant extract for osteoarthritis tissue diseases etc • Technology Transfer : Cost effective wound dressing materials

  14. Financial status (as on 1-10-.2016)

  15. Plan for the next half year (Oct-Mar 2017) Note: The balance amount shall be exhausted by January 2017 and an additional fund Rs. 71 lakhs is requested

  16. Sustainability Plan after Project closure

  17. Key Issues/Concerns Pertaining to the Centre • Too much delay in getting approval for establishment of animal house facility (mandatory for FDA Approval) • Clean Room Facility is required for manufacturing clinical grade products (mandatory for FDA Approval) which is under pipeline under main TEQIP-II • Requirement of man power on permanent basis like faculty, scientist, technical/supporting staffs etc.

  18. Future Work • Generation of Tissue Grafts with the developed scaffold and stem cells • In vivo animal testing of the scaffold and tissue grafts ( in collaboration with Advanced Cell Pvt. Ltd Noida) • Fabrication of Rapid prototyping machine & its possible commercialization • Development of skin substitutes for burn patient (in collaboration with AIIMs) • Drug screening Kit with the developed construct (associated product)

  19. Thank you

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