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MHRD Fast Program

Discover the advancements in generating tissue grafts using novel scaffolds and stem cells, as well as the development of cryopreservation technologies. Explore notable achievements, future goals, industry collaborations, and outreach efforts to rural communities.

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MHRD Fast Program

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  1. CoE in Tissue Engineering Presented by MHRD Fast Program National Institute of Technology, Rourkela

  2. Objective of the Center Development of Infrastructure /Research Facility of International Standard Development of research facility of International Standard Teaching & Training Development of research facility of International Standard Research & Development • Societal development Development of research facility of International Standard

  3. Research Objectives… Development of novel Scaffolds for tissue engineering application Biomechanics Cryo preservation of hMSCs, derived from Different sources & constructs & Grafts Cryo preservation of tissue engineered Bone, cartilage muscle & Skin Grafts Tissue Engineering Group & Its research Bone, Cartilage, Skeletal muscle Tissue Engineering Genetic reprogramming of cells for tissue engineering application Bimicrofluidics based microreactor for cell culture. Lab-on-Chip system for tissue engineering application Development of smart material Surface modification of biomaterials

  4. Progress in during April-Sept, 2006

  5. Focus areas of research • Development of engineered bone scaffolds & Bone tissue graft • Development of engineered Cartilage scaffold & cartilage tissue graft • Development of engineered musculo skeletal scaffolds & Muscle tissue graft • Production of Stem Cell • Development of Cryopreservation technology for stem celss and tissue grafts

  6. Publication(April-Sept 2016) • B.N. Singh, N.N. Panda, R. Mund, K. Pramanik (2016) Carboxymethyl cellulose enables silk fibroin nanofibrous scaffold with enhanced biomimetic potential for bone tissue engineering application, Carbohydrate Polymer, 151, 335-347. (Elsevier, IF: 4.689) • Serum-free non-toxic freezing solution for cryopreservation of human adipose tissue-derived mesenchymal stem cells, S S Ray, K. Pramanik, S. K. Sarangi, N Jain (2016) Biotechnology Letter, 38, 1397-404. (Springer, IF:1.639) • K. Pal, S. S. Sagiri, V. K. Singh, B. Behera, I. Banerjee, K. Pramanik (2016) “Natural Polymers in Tissue Engineering: Methods of scaffold fabrication and Applications” in “Encyclopedia of Biomedical Polymers and Polymeric Biomaterials”, Taylor & Francis Group, USA, p-5619-5649. • T. Kaur, A. Thirugnanam and K. Pramanik, Carbon nanomaterials reinforced poly(lactic-co-glycolic acid) composites for bone tissue engineering, World Biomaterials Congress May 2016, Montreal, Canada • M. Sivasankari, K. Pramanik, Silk based tissue engineering construct using rapid prototyping technique. International conference on Biomaterial, Biodignostics, Tissue Engg. Drug Delivery and Regenerative Medicine April 15-17 2016 at IIT Delhi, India. • B.N. Singh, K. Pramanik, A Novel Approach To Fabricate Aqueous Silk Fibroin Based Nanofibrous Mats With Enhanced Mechanical Properties, International conference  on Biomaterial, Biodignostics, Tissue Engineering, Drug Delivery and Regenerative Medicine April 15-17 2016 at IIT Delhi, India.

  7. Notable achievements: Patents/Products/Prototypes developed so far

  8. A snap of technology/product/device development Chitosan/β-TCP composite scaffolds & SEM image

  9. Snap shots contd… Bone construct Cartilage Constructs Constructs generation in bioreactor

  10. Snap shots contd… Cell – Seeded Scaffold

  11. Snap Shot cont.--- In house built 3D printing machine & fabricated scaffold Small Scale Stem Cell Banking Facility

  12. Interaction with industry, relevance to Indian Technology needs, Economic Advancements resulting as a consequence

  13. Adoption of Villages Project Area : Rural Village (s) : Santospur Block/Taluka : Bishra District : Sundargarh State : Odisha • Healthcare awareness program: General health care issues like sanitation, food & nutrition, common infection & prevention • Motivating & capacity building by launching micro-enterprises in the area of cultivation of medicinal plant & preparation of plant extract for osteoarthritis tissue diseases etc • Technology Transfer : Cost effective wound dressing materials

  14. Financial status (as on 1-10-.2016)

  15. Plan for the next half year (Oct-Mar 2017) Note: The balance amount shall be exhausted by January 2017 and an additional fund Rs. 71 lakhs is requested

  16. Sustainability Plan after Project closure

  17. Key Issues/Concerns Pertaining to the Centre • Too much delay in getting approval for establishment of animal house facility (mandatory for FDA Approval) • Clean Room Facility is required for manufacturing clinical grade products (mandatory for FDA Approval) which is under pipeline under main TEQIP-II • Requirement of man power on permanent basis like faculty, scientist, technical/supporting staffs etc.

  18. Future Work • Generation of Tissue Grafts with the developed scaffold and stem cells • In vivo animal testing of the scaffold and tissue grafts ( in collaboration with Advanced Cell Pvt. Ltd Noida) • Fabrication of Rapid prototyping machine & its possible commercialization • Development of skin substitutes for burn patient (in collaboration with AIIMs) • Drug screening Kit with the developed construct (associated product)

  19. Thank you

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